Wisconsin Discovery Portal

Researcher: Adel Talaat

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Areas of Expertise
  • Bacteria
  • Epidemiology
  • Immunology
  • Mycology
  • Parasitology
  • Anatomical and clinical pathology
  • Microbial pathogenesis
  • Functional genomics
  • Evolution of bacterial genomes
  • Bacterial pathogenesis and evolution on a genome-wide scale
  • Mycobacterium tuberculosis
  • Array differential gene expression (ADGE) profiling
  • Transcriptional machinery that underlies mycobacterial virulence
  • Gene-targeted mutational analysis alongside cellular, biochemical, and molecular techniques
  • Role of a novel genomic island expressed only during infection
  • Pathogenesis of M. Avium SS. paratuberculosis (M. Ap)
  • Johne's disease in cattle
Web Site Adel Talaat's School of Veterinary Medicine Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,220,764 - Immunogenic compositions against tuberculosis, issued December 2015.
  • 8,758,773 - Vaccine candidates against johne's disease, issued June 2014.
  • 8,367,055 - Immunogenic compositions against tuberculosis, issued February 2013.
USPTO Published Applications
  • 20160175420 - Immunogenic compositions against tuberculosis, published June 2016.
  • 20160123979 - Biomarkers for early diagnosis and differentiation of mycobacterial infection, published May 2016.
  • 20140322256 - Vaccine candidates against Johne's disease, published October 2014.
  • 20140271719 - Global gene regulators (GGR) as vaccine candidates against paratuberculosis, published September 2014.
  • 20130202642 - Immunogenic compositions against tuberculosis, published August 2013.
Recent Publication(s)
  • Csor is essential for maintaining copper homeostasis in mycobacterium tuberculosis. Marcus SA, Sidiropoulos SW, Steinberg H, Talaat AM. PLoS One. 2016 Mar 21;11(3):e0151816. doi: 10.1371/journal.pone.0151816. eCollection 2016.

  • Superior protection elicited by live-attenuated vaccines in the murine model of paratuberculosis. Ghosh P, Shippy DC, Talaat AM. Vaccine. 2015 Dec 16;33(51):7262-70. doi: 10.1016/j.vaccine.2015.10.116. Epub 2015 Nov 5.

  • Protection by novel vaccine candidates, mycobacterium tuberculosis δmosr and δecha7, against challenge with a mycobacterium tuberculosis beijing strain. Marcus SA, Steinberg H, Talaat AM. Vaccine. 2015 Oct 13;33(42):5633-9. doi: 10.1016/j.vaccine.2015.08.084. Epub 2015 Sep 9.

  • Virtual screening for udp-galactopyranose mutase ligands identifies a new class of antimycobacterial agents. Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL. ACS Chem Biol. 2015 Oct 16;10(10):2209-18. doi: 10.1021/acschembio.5b00370. Epub 2015 Aug 17.
Recent Artistic Works
Collaboration
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-2861
Current University UW–Madison
Department Animal Health and Biomedical Sciences / Pathobiological Sciences
Title Professor
Other Appointments
Address Line 1 303 Hanson Biomedical Sciences Building
Address Line 2 1656 Linden Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.V.S., Cairo University, Egypt, Veterinary Medicine, 1986
Master's Degree M.V.S., Cairo University, Egypt, Veterinary Medicine, 1990
PhD Ph.D., University of Maryland, 1998
Other Degrees
Technologies Available for Licensing Vaccine Candidates Against Johne's Disease

Novel Candidates for an Improved Tuberculosis Vaccine

Potential for Vaccine Against Johne’s Disease