Wisconsin Discovery Portal

Researcher: Aseem Ansari

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Areas of Expertise
  • Regulation of gene expression at the interface of chemistry, biology, and genomics
  • Mechanistic events that culminate in the expression of specific genes
  • Artificial transcription factors capable of regulating the expression of targeted genes
  • Biochemical and genomic/proteomic tools to understand how Cdk8/Srb10 mediates orthogonal roles
  • Small molecule regulators that are capable of binding to specific DNA sequences and regulating the expression of proximal genes
  • Genome-wide expression patterns to determine if chemicals reprogram a common set of transcriptional circuits which then suffice to induce differentiation
  • The ability of designer transcriptional regulators to stimulate specific transcriptional circuits and thus to identify the minimal set of circuits required to trigger differentiation
Web Site Aseem Ansari's University Web Page
Curriculum Vitae (CV)
Issued Patent(s)  
USPTO Published Applications
  • 20100160178 - System and method for presenting DNA binding specificities using specificity landscapes, published June 2010.
  • 20100016172 - Nucleic acid binding assay materials and methods, published January 2010.
Recent Publication(s)
  • Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers. Eguchi A, Lee G, Wan F, Erwin G, Ansari A. Biochem J. 2014 September 15;462(3):397-413. doi: 10.1042/BJ20140400.

  • Mapping olyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites. Erwin G, Bhimsaria D, Eguchi A, Ansari A. Angew Chem Int Ed Engl. 2014 September 15;53(38):10124-10128. doi: 10.1002/anie.201405497. Epub 2014 July 27.

  • The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally. Park D, Akhtar M, Ansari A, Landick R, Kiley P. PLoS Genet. 2013;9(10):e1003839. doi: 10.1371/journal.pgen.1003839. Epub 2013 October 17.

  • Gene loops enhance transcriptional directionality. Tan-Wong S, Zaugg J, Camblong J, Xu Z, Zhang D, Mischo H, Ansari A, Luscombe N, Steinmetz L, Proudfoot N. Science. 2012 November 2;338(6107):671-675. doi: 10.1126/science.1224350. Epub 2012 September 27.

View Aseem Ansari's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Biomedical Engineering, Anatomy, Medicine, Materials Science
  • University of Oxford, Pathology
Research Tools
Research Facilities
  • Genome Center of Wisconsin
E-mail Address [email protected]
Phone Number 608-265-4690
Current University UW–Madison
Department Biochemistry / Center for South Asia
Title Professor
Other Appointments
Genome Center of Wisconsin, Khorana Program
Address Line 1 315C DeLuca Biochemistry Laboratories
Address Line 2 433 Babcock Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.Sc., Bombay University, 1987
Master's Degree
PhD Ph.D., Northwestern University, 1995
Other Degrees Postdoc, Harvard University and MIT
Technologies Available for Licensing