Wisconsin Discovery Portal

Researcher: Margaret Clagett-Dame

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Areas of Expertise
  • Cellular regulation
  • Molecular genetics
  • Protein structure
  • Hormone action
  • Cell biology
  • Molecular mechanism of action of vitamin A in embryonic development
  • Vitamin A and neuronal survival and differentiation
  • Retinoids in chemoprevention and chemotherapy
Web Site Margaret Clagett-Dame's Department of Biochemistry Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,290,447 - (20R) and (20S)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin D.sub.3 analogs and their uses , issued March 2016.
  • 9,205,096 - Use of 2-methylene-19-nor-(20S)-1.alpha.,25-dihydroxyvitamin D.sub.3 to treat secondary hyperparathyroidism, issued December 2015.
  • 9,034,853 - Use of 2-methylene-19-nor-(20S)-1.alpha.,25-dihydroxyvitamin D.sub.3 to treat secondary hyperparathyroidism, issued May 2015.
  • 8,993,547 - 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses, issued March 2015.
  • 8,987,235 - N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses, issued March 2015.
USPTO Published Applications
  • 20150374722 - Once-a-week administration of 25-Hydroxy vitamin D3 to sustain elevated steady-state Pharmacokinetic Blood Concentration, published December 2015.
  • 20140206655 - (22E)-2-Methylene-22-Dehydro-1Alpha,24,25-Trihydroxy-19-NOR-vitamin D3 analogs, published July 2014.
  • 20140187522 - Use of 2-Methylene-19-Nor-(20S)-1alpha,25-Dihydroxyvitamin D3 to treat secondary hyperparathyroidism, published July 2014.
  • 20140018332 - Methods of use to orally and topically treat acne and other skin conditions by administering a 19-Nor containing vitamin d analog with or without a retinoid, published January 2014.
Recent Publication(s)
  • Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment. Knutson DC, Mitzey AM, Talton LE, Clagett-Dame M. Brain Res. 2016 Feb 1;1632:141-55. doi: 10.1016/j.brainres.2015.12.005. Epub 2015 Dec 10.

  • A complex RARE is required for the majority of Nedd9 embryonic expression. Knutson DC, Clagett-Dame M. Transgenic Res. 2015 Feb;24(1):123-34. doi: 10.1007/s11248-014-9825-9. Epub 2014 Aug 14.

  • Novel, selective vitamin D analog suppresses parathyroid hormone in uremic animals and postmenopausal women. Zella JB, Plum LA, Plowchalk DR, Potochoiba M, Clagett-Dame M, DeLuca HF. Am J Nephrol. 2014;39(6):476-83. doi: 10.1159/000362846. Epub 2014 May 17.

  • 26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine. Chiellini G, Grzywacz P, Plum LA, Clagett-Dame M, DeLuca HF. Steroids. 2014 May;83:27-38. doi: 10.1016/j.steroids.2014.01.012. Epub 2014 Feb 7.


View Margaret Clagett-Dame's publications at PubMed.
Recent Artistic Works
Collaboration
  • Intra University Collaboration: Chemistry, Biochemistry
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-3450
Current University UW–Madison
Department Biochemistry
Title Professor
Other Appointments
Address Line 1 241E DeLuca Biochemistry Laboratories
Address Line 2 433 Babcock Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Pennsylvania State University
Master's Degree M.S., Pennsylvania State University
PhD Ph.D., UW–Madison
Other Degrees
Technologies Available for Licensing Modified Retinoid Compounds with Reduced Toxicity

Analogs of Retinamide and Method of Using the Same to Inhibit Neoplastic Cell Growth

Preparations and Uses of an Endogenous Aryl Hydrocarbon Receptor

TTNPB Analogs Useful for Preventing or Treating Cancer

2-Methylene-18,19-Dinor-1Alpha-Hydroxy-Homopregnacalciferol

2-Methylene-19-Nor-1Alpha-Hydroxy-17-Ene-Homopregnacalciferol

2-Methylene-19,21-Dinor-1Alpha-Hydroxy-Bishomopregnacalciferol

C-linked Analogs of N-(4-hydroxyphenyl) Retinamide

Calcitonin and Calcitonin-Like Compounds for Multiple Sclerosis

Vitamin D Analog “N-23” for Cancer Prevention and Treatment

Vitamin D Analog for Cancer Prevention and Treatment

Vitamin D Analog “Me-Cvit” Potentially Useful to Inhibit Hypercalcemia, Treat Cancer

Vitamin D Analogs “DO-REVA” and “DO-REVB” for Cancer Prevention and Treatment

Vitamin D Analogs “WT-51” and “WT-52” Boost Bone and Skin Health

Vitamin D Analogs for Treating Bone Cancers and Diseases

Vitamin D Analog “CPA-1” for Treating and Preventing Deadliest Cancers

Vitamin D Analog “TS-17” for the Treatment of Cancer, Particularly Leukemia and Lung Cancer

Vitamin D Analog “DA2HE” to Treat and Prevent Polyps, Hyperplastic Intestinal Disorders

Vitamin D Analog “UW-05” for Skin Therapy, Parathyroid and Autoimmune Disease Treatment