Wisconsin Discovery Portal

Researcher: Michael Cox

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Areas of Expertise
  • Genetic recombination
  • DNA repair
  • RecA protein
  • The Ref protein, a programmable nuclease
  • The MgsA/RarA protein
  • Recombinational DNA repair in E. coli
  • Repair of double strand breaks during chromosome restoration
  • Deinococcus radiodurans
  • Enhanced/directed evolution of radiation resistance in E. coli
  • The RadD (YejH) protein
  • DNA polymerase V mechanism
  • Resistance to extreme levels of ionizing radiation
Web Site Michael Cox's Department of Biochemistry Website
Curriculum Vitae (CV) Michael Cox's CV
Issued Patent(s)
  • 8,785,157 - Method for using ref protein as a targeted reca-dependent nuclease, issued July 2014.
  • 8,586,362 - Method for DNA double-strand break repair in vitro and applications thereof, issued November 2013.
  • 7,550,564 - Method to protect DNA ends, issued June 2009.
  • 7,211,393 - Method to protect DNA ends, issued May 2007.
  • 7,176,007 - RecA mutants, issued February 2007.
USPTO Published Applications
  • 20140134628 - Method for dna double-strand break repair in vitro and applications thereof, published May 2014.
  • 20120088276 - Method for using ref protein as a targeted reca-dependent nuclease, published April 2012.
  • 20100317009 - Method for dna double-strand break repair in vitro and applications thereof, published December 2010.
  • 20070249810 - Method to protect dna ends, published October 2007.
  • 20060024698 - Method to protect dna ends, published February 2006.
Recent Publication(s)
  • Escherichia coli radd protein functionally interacts with the single-stranded dna-binding protein. Chen SH, Byrne-Nash RT, Cox MM. J Biol Chem. 2016 Sep 23;291(39):20779-86. doi: 10.1074/jbc.M116.736223.

  • Mutations for worse or better: Low-fidelity dna synthesis by sos dna polymerase v is a tightly regulated double-edged sword. Jaszczur M, Bertram JG, Robinson A, van Oijen AM, Woodgate R, Cox MM, Goodman MF. Biochemistry. 2016 Apr 26;55(16):2309-18. doi: 10.1021/acs.biochem.6b00117. Epub 2016 Apr 12.

  • P1 ref endonuclease: A molecular mechanism for phage-enhanced antibiotic lethality. Ronayne EA, Wan YC, Boudreau BA, Landick R, Cox MM. PLoS Genet. 2016 Jan 14;12(1):e1005797. doi: 10.1371/journal.pgen.1005797. eCollection 2016 Jan.

  • Structural and functional studies of h. seropedicae reca protein - insights into the polymerization of reca protein as nucleoprotein filament. Leite WC, Galvão CW, Saab SC, Iulek J, Etto RM, Steffens MB, Chitteni-Pattu S, Stanage T, Keck JL, Cox MM. PLoS One. 2016 Jul 22;11(7):e0159871. doi: 10.1371/journal.pone.0159871. eCollection 2016.

View Michael Cox's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Biomolecular Chemistry, Biotechnology Center
  • Washington University, Biochemistry, Molecular Biophysics
  • University of Southern California, Biological Sciences, Chemistry
  • Louisiana State University, Biological Sciences
  • National Taiwan University, Chemistry
  • National Institutes of Health, Laboratory of Genomic Integrity
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-1181
Current University UW–Madison
Department Biochemistry
Title Professor
Other Appointments
Address Line 1 341B DeLuca Biochemistry Laboratories
Address Line 2 433 Babcock Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.A., University of Delaware, Biology, 1974
Master's Degree
PhD Ph.D., Brandeis University, Biochemistry, 1979
Other Degrees
Technologies Available for Licensing Using Conjugated Linoleic Acid to Inhibit Cyclooxygenase-2 and Reduce Inflammation

Cleaving Double-Stranded DNA at User-Chosen Sites

Improved Ref Nuclease for Site-Specific DNA Cleavage

Double-Strand DNA Break Repair in Vitro – Forensic and Genomic Applications