Wisconsin Discovery Portal

Researcher: Brian Fox

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Areas of Expertise
  • Biochemical, catalytic, and spectroscopic studies of redox active enzymes
  • Protein engineering
  • Structure and reactivity of the active site diiron center
  • Catalytic contributions to the active site protein residues
  • Consequences of protein-protein and protein-substrate interactions on the outcome of enzyme catalysis
  • Fermentation
Web Site Brian Fox's Department of Biochemistry Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,145,551 - Multifunctional cellulase and hemicellulase, issued September 2015.
  • 8,945,902 - Combinatorial discovery of enzymes with utility in biomass transformation, issued February 2015.
  • 8,268,581 - Carboxy terminal residues as predictors and regulators of protein stability, issued September 2012.
  • 8,088,601 - Expression systems for functional membrane polypeptides, issued January 2012.
  • 7,601,358 - Mycobacterium tuberculosis protein composition, issued October 2009.
USPTO Published Applications
  • 20140079683 - Multifunctional cellulase and hemicellulase, published March 2014.
  • 20120107904 - Carboxy terminal residues as predictors and regulators of protein stability, published May 2012.
  • 20100330649 - Expression systems for functional membrane polypeptides, published December 2010.
  • 20100304405 - Combinatorial discovery of enzymes with utility in biomass transformation, published December 2010.
  • 20080286749 - Enhanced protein expression using auto-induction media, published November 2008.
Recent Publication(s)
  • Cell-free translation and purification of arabidopsis thaliana regulator of g signaling 1 protein. Li B, Makino S, Beebe ET, Urano D, Aceti DJ, Misenheimer TM, Peters J,Fox BG, Jones AM. Protein Expr Purif. 2016 Oct;126:33-41. doi: 10.1016/j.pep.2016.04.016. Epub 2016 May 6.

  • Evolution and ecology of actinobacteria and their bioenergy applications. Lewin GR, Carlos C, Chevrette MG, Horn HA, McDonald BR, Stankey RJ,Fox BG, Currie CR. Annu Rev Microbiol. 2016 Sep 8;70:235-54. doi: 10.1146/annurev-micro-102215-095748.

  • Evolution of high cellulolytic activity in symbiotic streptomyces through selection of expanded gene content and coordinated gene expression. Book AJ, Lewin GR, McDonald BR, Takasuka TE, Wendt-Pienkowski E, Doering DT, Suh S, Raffa KF, Fox BG, Currie CR. PLoS Biol. 2016 Jun 8;14(6):e1002475. doi: 10.1371/journal.pbio.1002475. eCollection 2016 Jun.

  • Structure of t4mof, the toluene 4-monooxygenase ferredoxin oxidoreductase. Acheson JF, Moseson H, Fox BG. Biochemistry. 2015 Sep 29;54(38):5980-8. doi: 10.1021/acs.biochem.5b00692. Epub 2015 Sep 17.

View Brian Fox's publications at PubMed.
Recent Artistic Works
  • Envirogen, Inc.
  • Intra-University Collaboration: Chemistry, Great Lakes Bioenergy Research Center
  • University of Wisconsin-Oshkosh, Chemistry
  • Carnegie Mellon University
  • Hokkaido University, Agriculture
  • California State University-Fullerton, Chemistry, Biochemistry
  • Oregon Graduate Institute
  • Brookhaven National Lab
  • Joint Genome Institute
Research Tools
  • High-Resolution NMR
  • Computer-Controlled Fermenter
  • Optical and Resonance Raman Spectroscopies
  • X-Ray
Research Facilities
  • Institute for Enzyme Research
E-mail Address [email protected]
Phone Number 608-265-2507
Current University UW–Madison
Department Biochemistry / Administration
Title Professor
Other Appointments Associate Vice Chancellor
Address Line 1 141B DeLuca Biochemistry Laboratories
Address Line 2 433 Babcock Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.A., Carleton College
Master's Degree
PhD Ph.D., University of Minnesota
Other Degrees
Technologies Available for Licensing Fluorescence Polarization Assay to Detect Protease Cleavage

Expression System and Fermentation Processes For Overexpression Of Holo-Acyl Carrier Protein

Simpler Method of Producing Functional Cytochrome B5 and Other Membrane Polypeptides

Controlling and Predicting the Stability of a Protein Against Degradation by Proteases

Powerful New Enzyme for Transforming Biomass

Cell-Free System for Combinatorial Discovery of Enzymes Capable of Transforming Biomass for Biofuels

Enhanced Biomass Digestion with Wood Wasp Bacteria