Wisconsin Discovery Portal

Researcher: Laura Kiessling

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Areas of Expertise
  • Cellular regulation
  • Molecular genetics
  • Protein structure
  • Hormone action
  • Cell biology
  • Biomolecular recognition processes
  • Chemistry and biology of protein-saccharide interactions
  • Synthetic methods that provide access to biologically active compounds for hypothesis driven discovery and research
  • New strategies for peptide/protein synthesis that provide access to sequences with critical posttranslational modifications (glycosylation or tyrosine sulfation)
  • Synthesizes multivalent ligands that can be used to control receptor position
Web Site Laura Kiessling's Department of Biochemistry Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,206,271 - Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP), issued December 2015.
  • 8,642,337 - Defined surfaces of self-assembled monolayers and stem cells, issued February 2014.
  • 7,807,140 - Magnetic resonance imaging contrast agents synthesized using ring-opening metathesis polymerization, issued October 2010.
  • 7,317,129 - Chemical synthesis of reagents for peptide coupling, issued January 2008.
  • 7,301,006 - Methods and materials for the synthesis of modified peptides, issued November 2007.
USPTO Published Applications
  • 20160131649 - Microbial glycans as a target of human intelectin, published May 2016.
  • 20150344501 - Inhibitors of udp-galactopyranose mutase, published December 2015.
  • 20140287505 - Peptide-presenting surfaces for long-term culture of pluripotent cells, published September 2014.
  • 20140112975 - Lipid-conjugated rhamnose for immune system recruitment and oncotherapy, published April 2014.
  • 20130281644 - Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP), published October 2013.
Recent Publication(s)
  • Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition. Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT. J Biol Chem. 2016 Mar 11;291(11):5596-610. doi: 10.1074/jbc.M115.709212. Epub 2016 Jan 11.

  • Carbohydrate-Aromatic Interactions in Proteins. Hudson KL, Bartlett GJ, Diehl RC, Agirre J, Gallagher T, Kiessling LL, Woolfson DN. J Am Chem Soc. 2015 Dec 9;137(48):15152-60. doi: 10.1021/jacs.5b08424. Epub 2015 Nov 30.

  • Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents. Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL. ACS Chem Biol. 2015 Oct 16;10(10):2209-18. doi: 10.1021/acschembio.5b00370. Epub 2015 Aug 17.

  • Recognition of microbial glycans by human intelectin-1. Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT,Kiessling LL. Nat Struct Mol Biol. 2015 Aug;22(8):603-10. doi: 10.1038/nsmb.3053. Epub 2015 Jul 6.


View Laura Kiessling's publications at PubMed.
Recent Artistic Works
Collaboration
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-0541
Current University UW–Madison
Department Biochemistry / Chemistry
Title Professor
Other Appointments
Address Line 1 5132A Chemistry Building
Address Line 2 1101 University Avenue
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Massachusetts Institute of Technology, 1983
Master's Degree
PhD Ph.D., Yale University, 1989
Other Degrees
Technologies Available for Licensing Chemical Synthesis of Reagents for Peptide Coupling

Synthesis of Proteins and Peptides Selectively Modified by Sulfation, Phosphorylation or Glycosylation

Defined Surfaces of Self-Assembled Monolayers and Stem Cells

Synthesis of Magnetic Resonance Imaging Contrast Agents Using Ring-Opening Metathesis Polymerization

Novel UGM Inhibitors for the Treatment of Tuberculosis and Other Microbial Infections

Methods and Reagents for Capping Ruthenium or Osmium Carbene-Catalyzed ROMP Products

Staudinger Ligation Method for Rapid and Reliable Chemical Synthesis of Proteins

Functional and Degradable ROMP Polymers for Plastics and Biomaterial

Provoking Anti-Tumor Immune Response with Rhamnose

More Potent UGM Inhibitors for Treating Tuberculosis and Other Microbial Infections

Peptide-Presenting Surfaces for Culturing Pluripotent Cells