Wisconsin Discovery Portal

Researcher: James Ntambi

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Areas of Expertise
  • Cellular regulation
  • Molecular genetics
  • Protein structure
  • Hormone action
  • Cell biology
  • High carbohydrate diet induced lipogenesis
  • Tissue-specific role of scd
  • Cellular differentiation and hormonal dietary regulation of the stearoyl-coa desaturase (SCD) genes
  • Cell line of mouse fibroblasts (preadipocytes) that undergo differentiation into adipocytes in cell culture
  • Mechanisms that regulate the expression of the stearoyl-CoA desaturase gene (SCD)  and differentiation
  • Fatty acids, cholesterol, carbohydrates, peroxisome proliferators, temperature, and hormones in the regulation of stearoyl-CoA desaturase gene in different tissues
Web Site James Ntambi's Department of Biochemistry Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,188,064 - Vitamin D analogs for obesity prevention and treatment, issued May 2012.
  • 7,816,075 - Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents, issued October 2010.
  • 7,790,408 - Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents, issued September 2010.
  • 7,285,395 - Stearoyl-CoA desaturase 4 gene, issued October 2007.
  • 6,987,001 - Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents, issued January 2006.
USPTO Published Applications
  • 20150086534 - Methods of use of secretory IgA, published March 2015.
  • 20120164154 - Method for increasing insulin sensitivity and for treating and preventing type 2 diabetes, published June 2012.
  • 20110287084 - Method for reducing body fat and increasing lean body mass by reducing stearoyl-CoA desaturase 1 activity, published November 2011.
  • 20110060014 - Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents, published March 2011.
Recent Publication(s)
  • Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. Masuda M, Miyazaki-Anzai S, Keenan AL, Okamura K, Kendrick J, Chonchol M, Offermanns S, Ntambi JM, Kuro-O M, Miyazaki M. J Clin Invest. 2015 Oct 26;125(12):4544-58. doi: 10.1172/JCI82871.

  • Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice. Singh V, Chassaing B, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M. Cell Metab. 2015 Dec 1;22(6):983-96. doi: 10.1016/j.cmet.2015.09.028. Epub 2015 Oct 29.

  • Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys. Polewski MA, Burhans MS, Zhao M, Colman RJ, Shanmuganayagam D, Lindstrom MJ, Ntambi JM, Anderson RM. J Lipid Res. 2015 Aug;56(8):1461-70. doi: 10.1194/jlr.M057562. Epub 2015 Jun 10.

  • Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis. Marty AJ, Broman AT, Zarnowski R, Dwyer TG, Bond LM, Lounes-Hadj Sahraoui A, Fontaine J, Ntambi JM, Keleş S, Kendziorski C, Gauthier GM. PLoS Pathog. 2015 Jun 26;11(6):e1004959. doi: 10.1371/journal.ppat.1004959. eCollection 2015 Jun.


View James Ntambi's publications at PubMed.
Recent Artistic Works
Collaboration
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-3700
Current University UW–Madison
Department Biochemistry / Nutritional Sciences
Title Professor
Other Appointments
Address Line 1 Nutritional Sciences
Address Line 2 1415 Linden Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Makerere University, Uganda
Master's Degree M.S., Makerere University, Uganda
PhD Ph.D., Johns Hopkins University
Other Degrees
Technologies Available for Licensing Methods and Materials for Assaying Non-SCD1 Isoforms

Model for Stearoyl-CoA Desaturase Activity

Mouse Strains and Cells Useful to Investigate Tissue-Specific Roles of Stearoyl-CoA Desaturase Isoforms

Screening Assays Based on Stearoyl-CoA Desaturase for Diseases Related to Serum Levels of Triglycerides and VLDL