Wisconsin Discovery Portal

Researcher: Helen Blackwell

[ printable ]
Areas of Expertise
  • Synthetic methodology
  • Discovery of biologically active molecules
  • Combining elements of microwave assisted organic chemistry, solid-phase synthesis, and combinatorial chemistry
  • Plants and animals sense and response to invasion by pathogenic microbes
  • Microwave-assisted solid-phase organic reactions
  • Diversity-generating organic reactions
  • Synthesizing new classes of peptidomimetics
  • Protein-protein interactions involved in bacterial communication pathways
  • Binding of bacterial LuxR-type proteins to their cognate autoinducer ligands
  • Homodimerization
  • Gram-negative bacterial quorum sensing circuits
  • Small molecule macroarrays
Web Site Helen Blackwell's Department of Chemistry Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,815,943 - Modulation of bacterial quorum sensing with synthetic ligands, issued August 2014.
  • 8,624,063 - Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing, issued January 2014.
  • 8,618,327 - Antibacterial agents and methods of use thereof, issued December 2013.
  • 8,367,680 - Antibacterial small molecules and methods for their synthesis, issued February 2013.
  • 8,269,024 - Compounds and methods for modulating communication and virulence in quorum sensing bacteria, issued September 2012.
USPTO Published Applications
  • 20150080349 - Modulation of bacterial quorum sensing with synthetic ligands, published March 2015.
  • 20140142156 - Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing, published May 2014.
  • 20120277252 - Antibacterial agents and methods of use thereof, published November 2012.
  • 20110212860 - Modulation of bacterial quorum sensing with synthetic ligands, published September 2011.
  • 20110046195 - Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing, published February 2011.
Recent Publication(s)
  • Identification of unanticipated and novel n-acyl l-homoserine lactones (ahls) using a sensitive non-targeted lc-ms/ms method. Patel NM, Moore JD, Blackwell HE, Amador-Noguez D. PLoS One. 2016 Oct 5;11(10):e0163469. doi: 10.1371/journal.pone.0163469.

  • Chemical probes of quorum sensing: From compound development to biological discovery. Welsh MA, Blackwell HE. FEMS Microbiol Rev. 2016 Sep;40(5):774-94. doi: 10.1093/femsre/fuw009. Epub 2016 Jun 5. Review.

  • Highly stable, amide-bridged autoinducing peptide analogues that strongly inhibit the agrc quorum sensing receptor in staphylococcus aureus. Tal-Gan Y, Ivancic M, Cornilescu G, Yang T, Blackwell HE. Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8913-7. doi: 10.1002/anie.201602974. Epub 2016 Jun 8.

  • Structure-function analyses of a staphylococcus epidermidis autoinducing peptide reveals motifs critical for agrc-type receptor modulation. Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE. ACS Chem Biol. 2016 Jul 15;11(7):1982-91. doi: 10.1021/acschembio.6b00120. Epub 2016 May 18.


View Helen Blackwell's publications here.
Recent Artistic Works
Collaboration
  • Intra-University Collaboration: Bacteriology, Microbiology
  • National University of Singapore, Biochemistry
  • University of Tokyo, Chemical Biology and Biotechnology Lab
  • Texas Tech University, Surgery
  • SUNY Cortland, Chemistry
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-1503
Current University UW–Madison
Department Chemistry
Title Professor
Other Appointments
Address Line 1 5211A Chemistry Building
Address Line 2 1101 University Avenue
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.A., Oberlin College, 1994
Master's Degree
PhD Ph.D., California Institute of Technology, 1999
Other Degrees
Technologies Available for Licensing Antibacterial Agents Using Small Molecule Macroarrays

Compounds and Methods for Modulating Communication and Virulence in Quorum Sensing Bacteria

Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria

Novel Antibacterial Small Molecules

Novel Antibacterial Agents That Modulate Quorum Sensing and Are Effective at Physiological pH

Combatting Biofilms by Disrupting Bacteria Quorum Sensing

Treating Staph Infections, Toxic Shock Syndrome by Disrupting Bacteria Quorum Sensing