Wisconsin Discovery Portal

Researcher: Samuel Gellman

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Areas of Expertise
  • Oligomers and polymers with well-defined folding properties
  • Catalytic foldamers
  • B-peptide tertiary structure and identification of b-peptides with useful activities
  • Protein-protein interactions
  • Two-dimensional NMR techniques
  • β-hairpin folding by NMR
  • Protein design
  • Minimal increments of secondary and tertiary structure
  • Efficient synthetic routes to new conformationally constrained g-peptide building blocks
  • a/g-and b/g peptides' promotion of helical conformation
  • HIV viral fusion
  • Mimicry of antimicrobial host-defense peptides
  • Backbone thioester exchange
  • Functionalized poly-β-peptides: Synthesis and aqueous self-assembly
Web Site Samuel Gellman's Laboratory Web Page
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,815,263 - Tandem facial amphiphiles, issued August 2014.
  • 8,772,450 - Beta-amino acids, issued July 2014.
  • 8,664,356 - Gamma amino acid building blocks, issued March 2014.
  • 8,642,536 - Method of making biologically active alpha-beta peptides, issued February 2014.
  • 8,637,696 - Methods for preparing amides and amino acids, issued January 2014.
USPTO Published Applications
  • 20140315791 - Method of making biologically active alpha-beta peptides, published October 2014.
  • 20140238939 - Immobilization of antimicrobial polymers on ro membrance to reduce biofilm growth and biofouling, published August 2014.
  • 20130324707 - Synthetic amphiphiles for membrane protein manipulation, published December 2013.
  • 20130177981 - Method of making biologically active alpha-beta peptides, published July 2013.
Recent Publication(s)
  • A γ-amino acid that favors 12/10-helical secondary structure in α/γ-peptides. Giuliano MW, Maynard SJ, Almeida AM, Guo L, Guzei IA, Spencer LC, Gellman SH. J Am Chem Soc. 2014 October 22;136(42):15046-15053. doi: 10.1021/ja5076585. Epub 2014 October 10.
  • Synthetic polymers active against clostridium difficile vegetative cell growth and spore outgrowth. Liu R, Suárez JM, Weisblum B, Gellman SH, McBride SM. J Am Chem Soc. 2014 October 3. [Epub ahead of print].
  • Ternary nylon-3 copolymers as host-defense peptide mimics: Beyond dydrophobic and cationic subunits. Chakraborty S, Liu R, Hayouka Z, Chen X, Ehrhardt J, Lu Q, Burke E, Yang Y, Weisblum B, Wong GC, Masters KS, Gellman SH. J Am Chem Soc. 2014 October 1. [Epub ahead of print].
  • A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, Gellman SH. J Am Chem Soc. 2014 September 17;136(37):12848-12851. doi: 10.1021/ja507168t. Epub 2014 September 5.

View Samuel Gellman's publications at Google Scholar.
Recent Artistic Works  
  • Intra-University Collaboration: Biomedical Engineering, Medicine
  • Georgetown University, Lombardi Cancer Center
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-3303
Current University UW–Madison
Department Chemistry
Title Professor
Other Appointments
Address Line 1 7132A Chemistry Building
Address Line 2 1101 University Avenue
City Madison
State WI
Zip Code 53706
Bachelor's Degree A.B., Harvard University, 1981
Master's Degree
PhD Ph.D., Columbia University, 1986
Other Degrees
Technologies Available for Licensing New Amphiphiles for Manipulating Integral Membrane Proteins

New Amphiphiles for Manipulating Membrane Proteins

Solubilizing and Characterizing Membrane Proteins Using Tandem Facial Amphiphiles

Treating Pulmonary Disorders with Artificial Lung Surfactant

Fast and Efficient Catalytic Metathesis of Secondary Amides for the Synthesis of Novel Molecules

Efficient Beta2-Amino Acid Synthesis Via Organocatalytic Aldehyde Aminomethylationlation

Beta-Peptides with Antifungal Activity

Pure, Cyclically-Constrained Gamma-Amino Acids for Medicine and Materials

Method for Synthesizing Beta-Polypeptides from Functionalized Beta-Lactam Monomers

Heterogeneous Protein Foldamers Containing Alpha, Beta and Gamma Amino Acids

Antimicrobial Polymers

Methods of Manufacturing and Using Beta-Peptide Lyotropic Liquid Crystals

New Tools for Solubilizing, Isolating and Characterizing Membrane Proteins

New Tools for Solubilizing, Isolating and Characterizing Membrane Proteins

Efficient Method of Synthesizing Gamma2-Amino Acids for Applications in Medicine, Materials, Healthcare