Wisconsin Discovery Portal

Researcher: Lloyd Smith

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Areas of Expertise
  • Analytical chemistry
  • Chemical biology
  • Development of novel methods and approaches for the analysis and manipulation of biomolecules
  • Biological mass spectrometry
  • DNA computing
  • Surface chemistry
  • Surface detection methods (fluorescence, surface plasmon resonance)
  • Analysis of genetic variations
  • Proteomics
Web Site Lloyd Smith's Department of Chemistry Website
Curriculum Vitae (CV) Lloyd Smith's CV
Issued Patent(s)
  • 9,651,487 - Surface plasmon resonance compatible carbon thin films, issued May 2017.
  • 8,686,375 - Molecule mass detection via field emission of electrons from membranes, issued April 2014.
  • 8,628,974 - Protein/peptide sequencing by chemical degradation in the gas phase, issued January 2014.
  • 8,592,216 - Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis, issued November 2013.
  • 8,563,777 - Ionizable isotopic labeling reagents for relative quantification by mass spectrometry, issued October 2013.
USPTO Published Applications
  • 20120022230 - Ionizable isotopic labeling reagents for relative quantification by mass spectrometry, published January 2012.
  • 20100330680 - Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis, published December 2010.
  • 20090321633 - Nanopillar arrays for electron emission, published December 2009.
  • 20090141376 - Surface plasmon resonance compatible carbon thin films, published June 2009.
  • 20080248585 - Protein/peptide sequencing by chemical degradation in the gas phase, published October 2008.
Recent Publication(s)
  • Chen, X., Lu, L., Mayer, K.S., Scalf, M., Qian, S., Lomax, A., Smith, L.M., Zhong, X. POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis, eLife, 2016;5:e17214.


  • Keller, M.P., Paul, K.P., Rabaglia, M.E., Stapleton, D.S., Schueler, K.L., Broman, A.T., Ye, S.I., Ling, N., Brandon, C.J., Neto, E.C., Plaisier, C.L., Simonett, S.P., Kebede, M.A., Sheynkman, G.M., Klein, M.A., Baliga, N.S., Smith, L.M., Broman, K.W., Yandell, B.S., Kendziorski, C., and Attie, A.D. The Transcription factor Nfatc2 regulates -cell proliferation and genes associated with Type 2 Diabetes in mouse and human islets. PLOS Genetics 12(12): e1006466. doi: 10.1371/journal.pgen.1006466.


  • Li, Q., Shortreed, M.R., Wenger, C.D., Frey, B., Scalf, M., Smith, L.M., 2016. Global Post-translational Modification Discovery, J. Proteome Res., DOI: 10.1021/acs.jproteome.6b00034. PMC5387672


  • Guillen-Ahlers, H., Rao, P., Levenstein, M., Kennedy-Darling, J., Perumalla, D., Jadhav, A., Glenn, J., Ludwig-Kubinski, A., Drigalenko, E., Montoya, M., Göring, H., Anderson, C., Scalf, M., Gildersleeve, H., Cole, R., Greene, A., Oduro, A., Lazarova, K., Cesnik, A., Barfknecht, J., Cirillo, L., Gasch, A., Shortreed, M., Smith, L., Olivier, M., 2016. HyCCAPP as a tool to characterize promoter DNA-protein interactions in Saccharomyces cerevisiae. Genomics, 107, 267-273. (NIHMSID788547)
Recent Artistic Works
Collaboration
  • University of Minnesota, Center for Mass Spectrometry and Proteomics
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-2594
Current University UW–Madison
Department Chemistry
Title Professor
Other Appointments
Director, Genome Center of Wisconsin
W. L. Hubbell Professor of Chemistry
Hall-Fischer Professor of Chemistry
Address Line 1 4209A Chemistry Building
Address Line 2 1101 University Avenue
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.A., University of California-Berkeley, 1976
Master's Degree
PhD Ph.D., Stanford University, 1981
Other Degrees
Technologies Available for Licensing Modified Carbon, Silicon & Germanium Surfaces for Biomolecular Arrays

New Method of Charge Reduction in Electrospray Mass Spectrometry

Piezoelectric Charged Droplet Source for Mass Spectrometry

Droplet Ion Source for Mass Spectrometry

Inductive Detection for Mass Spectrometry

Faster Gas-Phase Protein Sequencing

Electrospray Ionization Ion Source with Tunable Charge Reduction

Ionizable Isotopic Labeling Reagents for Relative Quantification by Mass Spectrometry

Reducing the Charges of Ions Generated by Electrospray Ionization for Mass Spectrometry

Improved Sensor Enables Sensitive Detection of Large Molecules in Mass Spectrometry

Improved Molecule Mass Detection Using Electron Field Emission from Kinetically Impacted Membranes

Robust Substrates Expand the Utility of Surface Plasmon Resonance Imaging for Analysis of Biomolecular Interactions

Parallel Measurements by Fluorescence and Mass Spectrometry for Absolute Quantification of Proteins

Labeling Peptides with Basic Functional Groups to Improve Mass Spectrometric Analysis

Assembly of Full-Length Genes from DNA Arrays