|Areas of Expertise
- Isolation and culture of non-human primate and human embryonic stem cells
- Demonstrating the developmental potential of human ES cells in lineage-specific differentiation
- How ES cells can form any cell in the body (pluripotency), and how an ES cell chooses between self renewal and the initial decision to differentiate
- How a differentiated cell with limited developmental potential can be reprogrammed to a pluripotent cell
- Examining the transcriptional networks in ES cells that mediate self-renewal and commitment to each of the basic lineages of the early embryo
- Mapping the epigenome of ES cells and their early-differentiated derivatives as a participant in the San Diego Epigenome Center
- Improving methods for generating human iPS cells, and correcting genetic defects in iPS cells generated from patients with degenerative retinal disease
- Developing new strategies to convert human pluripotent stem and somatic cells into hematopoietic, vascular, and cardiac progenitor cells
- Understanding clocking mechanisms that control developmental rates
||James Thomson's University Web Page
|Curriculum Vitae (CV)
- 9,023,644 - FGF having enhanced stability, issued May 2015.
- 8,785,189 - Method of forming dendritic cells from embryonic stem cells, issued July 2014.
- 8,772,460 - Thermostable FGF-2 mutant having enhanced stability, issued July 2014.
- 8,642,337 - Defined surfaces of self-assembled monolayers and stem cells, issued February 2014.
- 8,440,461 - Reprogramming somatic cells using retroviral vectors comprising Oct-4 and Sox2 genes, issued May 2013.
|USPTO Published Applications
- 20150056698 - Primate embryonic stem cells, published February 2015.
- 20140248699 - Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells, published September 2014.
- 20140057355 - Somatic cell reprogramming, published February 2014.
- 20130236962 - Medium and culture of embryonic stem cells, published September 2013.
- 20130230917 - Method of forming dendritic cells from embryonic stem cells, published September 2013.
- EBSeq-HMM: A Bayesian approach for identifying gene-expression changes in ordered RNA-seq experiments. Leng N, Li Y, McIntosh BE, Nguyen BK, Duffin B, Tian S, Thomson JA, Dewey CN, Stewart R, Kendziorski C. Bioinformatics. 2015 Apr 5. pii: btv193. [Epub ahead of print].
- A cost-effective RNA sequencing protocol for large-scale gene expression studies. Hou Z, Jiang P, Swanson SA, Elwell AL, Nguyen BK, Bolin JM, Stewart R, Thomson JA. Sci Rep. 2015 April 1;5:9570. doi: 10.1038/srep09570.
- Chromatin architecture reorganization during stem cell differentiation. Dixon JR, Jung I, Selvaraj S, Shen Y, Antosiewicz-Bourget JE, Lee AY, Ye Z, Kim A, Rajagopal N, Xie W, Diao Y, Liang J, Zhao H, Lobanenkov VV, Ecker JR, Thomson JA, Ren B. Nature. 2015 February 19;518(7539):331-336. doi: 10.1038/nature14222.
- Evaluation of de novo transcriptome assemblies from RNA-Seq data. Li B, Fillmore N, Bai Y, Collins M, Thomson JA, Stewart R, Dewey CN. Genome Biol. 2014 December 21;15(12):553. doi: 10.1186/s13059-014-0553-5.
|Recent Artistic Works
- Intra-University Collaboration: Statistics, Biostatistics and Medical Informatics
- Genome Center of Wisconsin
- University of California, San Diego, Bioinformatics and Systems Biology, Cellular and Molecular Medicine, Institute of Genomic Medicine, Ludwig Institute for Cancer Research
- Genome Sciences Centre, BC Cancer Research Center
- University of California Davis Comprehensive Cancer Center
- Tsinghua University, Life Sciences
- University of Illinois at Urbana-Champaign, Chemical and Biomolecular Engineering
- National Institute of Allergy and Infectious Diseases, Laboratory of Immunogenetics
- Howard Hughes Medical Institute, The Salk Institute for Biological Studies
||Cell and Regenerative Biology
||Director, Regenerative Biology, Morgridge Institute for Research
|Address Line 1
|Address Line 2
||330 North Orchard Street
||B.S., University of Illinois, Biophysics, 1981
||Ph.D., University of Pennsylvania, Molecular Biology, 1988
||VMD, University of Pennsylvania, 1985
|Technologies Available for Licensing
||Differentiation and Purification of Neural Precursors from Human Embryonic Stem Cells
In Vitro Differentiation of Neural Stem Cells and Neurons from Human Embryonic Stem Cells
Culturing Human Embryonic Stem Cells in Well Defined and Controlled Conditions
Differentiation and Purification of Neural Precursors from Human Embryonic Stem Cells
Hematopoietic Differentiation of Human Embryonic Stem Cells
Method for Generating Primate Trophoblasts
Method of Forming Dendritic Cells from Embryonic Stem Cells
Method of Making Embryoid Bodies from Primate Embryonic Stem Cells
Multipotent Lymphohematopoietic Progenitor Cells
Serum-Free Cultivation of Primate Embryonic Stem Cells
Defined Surfaces of Self-Assembled Monolayers and Stem Cells