Wisconsin Discovery Portal

Researcher: Robert Pearce

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Areas of Expertise
  • Sensory stimuli
  • Physiology and pharmacology of pain
  • Mechanisms
  • Chronic pain
  • Central nervous system function
  • Pathological pain
  • Mechanisms that general anesthetics alter central nervous system function
  • Basic molecular events that occur during receptor activation
  • Agonist binding, unbinding, and intra-molecular transitions between metastable states
  • How molecular events are affected by different classes of drugs
  • Electrophysiological recording and rapid drug application techniques
  • Perioperative care of surgical patients
Web Site Robert Pearce's Department of Anesthesiology Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,000,048 - Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics, issued April 2015.
USPTO Published Applications
  • 20080234389 - Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics, published September 2008.
Recent Publication(s)
  • Contrasting effects of the γ-Aminobutyric acid Type A receptor β3 subunit N265M mutation on loss of righting reflexes induced by etomidate and the novel anesthetic barbiturate R-mTFD-MPAB. Amlong CA, Perkins MG, Houle TT, Miller KW, Pearce RA. Anesth Analg. 2016 Jun 21. [Epub ahead of print]

  • Lipid-free fluoropolymer-based propofol emulsions and lipid reversal of propofol anesthesia in rats. Parks CL, Tucker W, Amlong CA, Mecozzi S, Pearce RA. Anesthesiology. 2016 Jun;124(6):1328-37. doi: 10.1097/ALN.0000000000001080.

  • Tonic inhibitory control of dentate gyrus granule cells by α5-Containing GABAA receptors reduces memory interference. Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U. J Neurosci. 2015 Oct 7;35(40):13698-712. doi: 10.1523/JNEUROSCI.1370-15.2015.

  • Etomidate impairs long-term potentiation in vitro by targeting α5-subunit containing GABAA receptors on nonpyramidal cells. Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U,Pearce RA. J Neurosci. 2015 Jul 1;35(26):9707-16. doi: 10.1523/JNEUROSCI.0315-15.2015.

View Robert Pearce's publications at PubMed.
Recent Artistic Works
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-0208
Current University UW–Madison
Department Anesthesiology
Title Professor and Chair
Other Appointments
Address Line 1 Box 3272 Clinical Science Center
Address Line 2 600 Highland Avenue
City Madison
State WI
Zip Code 53792
Bachelor's Degree
Master's Degree
PhD Ph.D., University of Virginia-Charlottesville
Other Degrees M.D., University of Virginia-Charlottesville, 1986
Technologies Available for Licensing