Wisconsin Discovery Portal

Researcher: William Dove

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Areas of Expertise
  • Human tumors
  • Prevention
  • Diagnosis
  • Prognosis
  • Epstein-barr viurs
  • Kaposi's sarcoma-associated herpes virus
  • Human cytomegalovirus
  • Human papillomaviruses
  • Hepatitis b virus
  • Hepatitis c virus
  • Colon cancer
  • Cancer genetics
  • Clinical genetics
  • Self-renewal of the mammalian intestinal epithelium
  • Neoplastic forms of mammalian intestinal epithelium
  • Controlled genetics of mouse models for intestinal cancer
  • Transposon tagging strategies with retroviruses and serum analysis
  • Mass spectrometry for molecular signatures of the neoplastic process
  • Genetics of quantitative modifiers of tumor susceptibility
  • Imaging methods to follow cancer progression and regression in live animals
Web Site William Dove's McArdle Laboratory for Cancer Research Website
Curriculum Vitae (CV) William Dove's CV
Issued Patent(s)
  • 7,897,834 - Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region, issued March 2011.
  • 6,949,692 - Method for identifying mutants and molecules, issued September 2005.
  • 5,780,236 - Method for identifying mutants and molecules, issued July 1998.
USPTO Published Applications
  • 20070143867 - Mutation in the rat Adenomatous Polyposis Coli gene within the human mutation hotspot region, published June 2007.
  • 20020133831 - Method for identifying mutants and molecules, published September 2002.
Recent Publication(s)
  • Cholecalciferol or 25-hydroxycholecalciferol neither prevents nor treats adenomas in a rat model of familial colon cancer. Irving AA, Plum LA, Blaser WJ, Ford MR, Weng C, Clipson L, DeLuca HF,Dove WF. J Nutr. 2015 Feb;145(2):291-8. doi: 10.3945/jn.114.204396. Epub 2014 Dec 24.

  • Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. Amos-Landgraf JM, Heijmans J, Wielenga MC, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V, Hommes DW, Shedlovsky A, Dove WF, van den Brink GR. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16514-9. doi: 10.1073/pnas.1323064111. Epub 2014 Nov 3.

  • The utility of Apc-mutant rats in modeling human colon cancer. Irving AA, Yoshimi K, Hart ML, Parker T, Clipson L, Ford MR, Kuramoto T,Dove WF, Amos-Landgraf JM. Dis Model Mech. 2014 Nov;7(11):1215-25. doi: 10.1242/dmm.016980. Epub 2014 Oct 2. Review.

  • The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. Ivancic MM, Irving AA, Jonakin KG, Dove WF, Sussman MR. Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.

View William Dove's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: McArdle Cancer Research Institute, Statistics, Waisman Center, Biostatistics & Medical Informatics
  • Vanderbilt University, Pathology
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-8854
Current University UW–Madison
Department Oncology / Genetics
Title Emeritus Professor
Other Appointments
Address Line 1 6551 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.A., Amherst College, Chemistry, 1958
Master's Degree
PhD Ph.D., California Institute of Technology, Chemistry, 1962
Other Degrees
Technologies Available for Licensing A Mutation in the Rat Adenomatous Polyposis Coli Gene within the Human Mutation Hotspot Region