Wisconsin Discovery Portal

Researcher: W. John Kao

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Areas of Expertise
  • Biomaterials and tissue engineering
  • Biomechanics
  • Biomedical imaging and optics
  • Cellular and molecular engineering
  • Instrumentation and devices
  • Neuroengineering
  • Systems and synthetic biology
  • Dynamic interaction amongst the host, biomimetic biomaterial constructs, and therapeutic entities in the promotion of host response and healing
  • In situ photopolymerized semi-interpenetrating network for dermal wounds
  • Underlying biology and the mechanisms of the wound healingevent from inflammation to granulation
  • End stage healing as mediated by biofunctionalized materials
  • Role of mesenchymal stem cells in wound healing
  • Material-mediated function of monocytes, keratinocytes, fibroblasts and the paracrine relationship thereof
  • In situ polymerized multifunctional materials via “click chemistry” for wound healing, drug delivery, and cell transplantation
  • Stroma-cancer axis using microfluidic ecm-mimics for drug screening and underlying pathology
  • Novel biomarkers and microscopy methods to analyze pancreatic ductal adenocarcinoma and correlate ecm remodeling with disease progression and outcome
Web Site John Kao's Department of Biomedical Engineering Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,025,901 - Bifunctional-modified hydrogels, issued September 2011.
USPTO Published Applications
  • 20100209509 - Bifunctional-modified hydrogels, published August 2010.
  • 20060100369 - Bifunctional-modified hydrogels, published May 2006.
  • 20050276858 - Bifunctional-modified hydrogels, published December 2005.
Recent Publication(s)
  • Comparison of picrosirius red staining with second harmonic generation imaging for the quantification of clinically relevant collagen fiber features in histopathology samples. Drifka CR, Loeffler AG, Mathewson K, Mehta G, Keikhosravi A, Liu Y, Lemancik S, Ricke WA, Weber SM, Kao WJ, Eliceiri KW. J Histochem Cytochem. 2016 Sep;64(9):519-29. doi: 10.1369/0022155416659249. Epub 2016 Jul 22.

  • A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers. Hanley CJ, Noble F, Ward M, Bullock M, Drifka C, Mellone M, Manousopoulou A, Johnston HE, Hayden A, Thirdborough S, Liu Y, Smith DM, Mellows T, Kao WJ, Garbis SD, Mirnezami A, Underwood TJ, Eliceiri KW, Thomas GJ. Oncotarget. 2016 Feb 2;7(5):6159-74. doi: 10.18632/oncotarget.6740.

  • Local delivery of allogeneic bone marrow and adipose tissue-derived mesenchymal stromal cells for cutaneous wound healing in a porcine model. Hanson SE, Kleinbeck KR, Cantu D, Kim J, Bentz ML, Faucher LD, Kao WJ, Hematti P. J Tissue Eng Regen Med. 2016 Feb;10(2):E90-100. doi: 10.1002/term.1700. Epub 2013 Feb 18.

  • Poly(ethylene glycol)-containing hydrogels modulate α-defensin release from polymorphonuclear leukocytes and monocyte recruitment. Lieberthal TJ, Cohen HC, Kao WJ. J Biomed Mater Res A. 2015 Dec;103(12):3772-80. doi: 10.1002/jbm.a.35519. Epub 2015 Jun 26.

View John Kao's publications at PubMed.
Recent Artistic Works
  • Virginia Commonwealth University, Biomedical Engineering
  • Intra-University Collaboration: Biomedical Engineering
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-2998
Current University UW–Madison
Department Biomedical Engineering
Title Professor
Other Appointments
Address Line 1 3140 Engineering Centers Building
Address Line 2 1550 Engineering Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Johns Hopkins University, Biomedical Engineering, 1991
Master's Degree M.S., Case Western Reserve University, Biomedical Engineering, 1994
PhD Ph.D., Case Western Reserve University, Macromolecular Science, 1996
Other Degrees
Technologies Available for Licensing Multi-Functional Matrix to Promote Wound Healing and for Other Biomedical Applications

Click Chemistry-Based Multi-Enhanced Biomaterials Help Heal Wounds