Wisconsin Discovery Portal

Researcher: William Murphy

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Areas of Expertise
  • Biomaterials and tissue engineering
  • Biomechanics
  • Biomedical imaging and optics
  • Cellular and molecular engineering
  • Instrumentation and devices
  • Neuroengineering
  • Systems and synthetic biology
  • Creation of new biomaterials using bioinspired approaches
  • Using biomaterials to define the stem cell microenvironment
  • Development of biomaterials for tissue regeneration (tissue engineering)
  • New approaches for drug delivery and gene therapy
  • Extracellular matrix signals and bioactive soluble signals, resulting in spatially and temporally modulated cell activity
  • Biomaterials that mimic the complex signaling environments of natural tissue development
  • Regeneration of a variety of human tissues
  • Bioinspired non-covalent assembly of materials
  • Assembly of composite biomaterials
  • Stem cell growth and differentiation
  • Growth factor delivery
Web Site William Murphy's Department of Biomedical Engineering Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,295,755 - Multilayer tissue regeneration system, issued March 2016.
  • 8,846,860 - Methods of decorating hydroxyapatite biomaterials with modular biologically active molecules, issued September 2014.
  • 8,778,869 - Tissue regeneration system, issued July 2014.
  • 8,642,516 - Chemically-defined arrays for screening cell-substrate interactions, issued February 2014.
  • 8,420,774 - Decorating hydroxyapatite biomaterials with modular biologically active molecules, issued April 2013.
USPTO Published Applications
  • 20160175800 - Covalently-immobilized hydrogel arrays in multi-well plates, published June 2016.
  • 20160017368 - Inorganic coatings for the enhancement of chemical transfection, published January 2016.
  • 20150293073 - Novel method for forming hydrogel arrays using surfaces with differential wettability, published October 2015.
  • 20150291930 - Hydrogel compositions for use in cell expansion and differentiation, published October 2015.
  • 20150291929 - Hydrogel compositions for use in promoting tubulogenesis, published October 2015.
Recent Publication(s)
  • Surface functionalization and dynamics of polymeric cell culture substrates. Krutty JD, Schmitt SK, Gopalan P, Murphy WL. Curr Opin Biotechnol. 2016 Jun 14;40:164-169. doi: 10.1016/j.copbio.2016.05.006. [Epub ahead of print] Review.

  • Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Belair DG, Schwartz MP, Knudsen T, Murphy WL. Acta Biomater. 2016 Jul 15;39:12-24. doi: 10.1016/j.actbio.2016.05.020. Epub 2016 May 13.

  • Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. Zhou X, Moussa FM, Mankoci S, Ustriyana P, Zhang N, Abdelmagid S, Molenda J, Murphy WL, Safadi FF, Sahai N. Acta Biomater. 2016 Jul 15;39:192-202. doi: 10.1016/j.actbio.2016.05.007. Epub 2016 May 6.

  • Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect. Aktas E, Chamberlain CS, Saether EE, Duenwald-Kuehl SE, Kondratko-Mittnacht J, Stitgen M, Lee JS, Clements AE, Murphy WL, Vanderby R. J Orthop Res. 2016 Apr 6. doi: 10.1002/jor.23258. [Epub ahead of print]
Recent Artistic Works
Collaboration
  • University of Chicago: Chemistry, Biochemistry and Molecular Biology, Physics, Surgery
  • University of Michigan-Ann Arbor: Biomedical Engineering, Chemical Engineering, Biologic and Materials Sciences
  • Tissue Regeneration Systems, Inc.
Research Tools
Research Facilities
  • Smart, Bioinspired Materials Laboratory
E-mail Address [email protected]
Phone Number 608-265-9978
Current University UW–Madison
Department Biomedical Engineering
Title Professor
Other Appointments
Address Line 1 5009 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.S., Illinois Wesleyan University, 1998
Master's Degree M.S., University of Michigan-Ann Arbor, 2000
PhD Ph.D., University of Michigan-Ann Arbor, 2002
Other Degrees
Technologies Available for Licensing Method and System for Delivering Nucleic Acid into a Target Cell

Modular Peptide Binds to Biomaterials and Promotes New Bone Formation

a href="http://www.warf.org/technologies/summary/P08447US.cmsx" target="_blank">Biomaterial Scaffolds for the Repair and Regeneration of Intervertebral Discs and Articulating Joints

Spatial Control of Signal Transduction

Bone Tissue Regeneration System That Provides Spatial and Temporal Control Over the Release of Growth Factors

Biologically Active Sutures Enhance Tissue Healing Following Surgical Procedures

An Orthopedic Implant Coating for Enhanced Bone Growth

Hydrogel Arrays for Screening Cell-Substrate Interactions, Now in Multiwell Format

Polymer Coating for Cell Culture Substrates

Regulating Stem Cell Behavior with High Throughput Mineral Coatings

Multilayer Tissue Regeneration System

Hydrogel Arrays for Screening Cell-Substrate Interactions

Controlling the Formation of Stem Cell Colonies with Tailored SAM Array

Investigating Cell-Surface Interactions via Chemical Array