Wisconsin Discovery Portal

Researcher: Sean Fain

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Areas of Expertise
  • Advanced dosimetry
  • Radiation oncology
  • Biomagnetism
  • Magnetic resonance imaging (MRI)
  • Molecular imaging (MICMIC)
  • Nanotechnology
  • Neutron/proton metrology
  • Nuclear medicine/PET
  • Radiation metrology
  • Radiation calibration
  • Radiation therapy
  • Ultrasound
  • Diagnostic X-ray imaging
  • Lung imaging using hyperpolarized gas MRI
  • Functional imaging
  • Fast MRI
  • Diffusion-weighted 3He MRI
  • Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging
Web Site Sean Fain's Department of Medical Physics Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,008,399 - System and method for joint reconstruction of spatial and spectral imaging data, issued April 2015.
  • 8,175,359 - Iterative highly constrained image reconstruction method, issued May 2012.
  • 7,994,785 - Method for simultaneously measuring T2* and diffusion with magnetic resonance imaging, issued August 2011.
  • 7,885,702 - Segmentation of the airway tree using hyperpolarized noble gases and diffusion weighted magnetic resonance imaging, issued February 2011.
  • 7,714,581 - RF coil assembly for magnetic resonance imaging and spectroscopy systems, issued May 2010.
USPTO Published Applications
  • 20140212012 - System and method for joint reconstruction of spatial and spectral imaging data, published July 2014.
  • 20090273344 - Method for simultaneously measuring t2* and diffusion with magnetic resonance imaging, published November 2009.
  • 20080275333 - Local MRI breast coil and method of use, published November 2008.
  • 20080231281 - RF coil assembly and method for practicing magnetization transfer on magnetic resonance imaging and spectroscopy systems, published September 2008.
  • 20080199063 - Iterative highly constrained image reconstruction method, published August 2008.
Recent Publication(s)
  • Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Higano NS, Hahn AD, Tkach JA, Cao X, Walkup LL, Thomen RP, Merhar SL, Kingma PS, Fain SB, Woods JC. Magn Reson Med. 2016 Mar 12. doi: 10.1002/mrm.26212. [Epub ahead of print]

  • Nox2 and Cyclosporine-Induced Renal Hypoxia. Djamali A, Wilson NA, Sadowski EA, Zha W, Niles D, Hafez O, Dorn JR, Mehner TR, Grimm PC, Hoffmann FM, Zhong W, Fain SB, Reese SR. Transplantation. 2016 Mar 4. [Epub ahead of print]

  • Using MRI to Reveal (and Resolve) the Complexity of Obstructive Lung Disease. Fain SB, Sorkness RL. Acad Radiol. 2016 Apr;23(4):393-5. doi: 10.1016/j.acra.2016.01.007. Epub 2016 Mar 2. No abstract available.

  • Redistribution of inhaled hyperpolarized 3He gas during breath-hold differs by asthma severity. Hahn AD, Cadman RV, Sorkness RL, Jarjour NN, Nagle SK, Fain SB. J Appl Physiol (1985). 2016 Mar 1;120(5):526-36. doi: 10.1152/japplphysiol.00197.2015. Epub 2015 Dec 3.

View Sean Fain's publications at PubMed.
Recent Artistic Works
  • Duke University Medical Center
  • University of Virginia
  • Children's Hospital of Philidelphia, Radiology
  • University of California, San Diego, Radiology
  • GE Healthcare
  • Intra-University Collaboration: Biostatistics and Medical Informatics, Pulmonary Medicine, SMPH Department of Pediatrics
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-0090
Current University UW–Madison
Department Medical Physics / Biomedical Engineering / Radiology
Title Professor
Other Appointments
Address Line 1 1113 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree
B.S., University of California, Davis, Geology
B.S., University of Minnesota, Physics
Master's Degree
PhD Ph.D., Mayo Graduate School, Biomedical Imaging and Biophysics, 2000
Other Degrees
Technologies Available for Licensing Improved Lung Disease Diagnostic Using Gas Contrast Agent Diffusion Weighted MRI to Segment the Lumen

Radio Frequency (RF) Coil for an Improved MRI System

Magnetic Resonance Imaging of Diffusion and T2 Using Multi-Echo Projection Acquisition

Probing Disease Chemistry with Joint Spatial and Spectral Imaging