Wisconsin Discovery Portal

Researcher: T. Rockwell Mackie

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Areas of Expertise
  • Advanced dosimetry
  • Radiation oncology
  • Biomagnetism
  • Magnetic resonance imaging (MRI)
  • Molecular imaging (WICMIC)
  • Nanotechnology
  • Neutron/proton metrology
  • Nuclear medicine/PET
  • Radiation metrology
  • Planning and delivery of radiation therapy to cancer patients
  • Tomotherapy
  • Compact proton therapy machine
  • Radiation physics
  • Computer physics
  • Radiation dosimetry
  • Radiation calibration and effects
  • Dose distributions in tissue, particularly in brachytherapy
  • Conformal treatment utilizing multimodality imaging
  • Measurement of radiation from various sources
  • Development and application of safety practices in radiation therapy
Web Site T. Rockwell Mackie's Department of Medical Physics Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,006,677 - Fan beam modulator for ion beams providing continuous intensity modulation, issued April 2015.
  • 8,897,857 - Method and apparatus for generating proton therapy treatment planning images, issued November 2014.
  • 8,778,252 - Three-dimensional printing system using dual rotation axes, issued July 2014.
  • 8,767,917 - System and method of delivering radiation therapy to a moving region of interest, issued July 2014.
  • 8,309,915 - Mass spectrometer using an accelerating traveling wave, issued November 2012.
USPTO Published Applications
  • 20160056008 - System and method for multi-source x-ray-based imaging, published February 2016.
  • 20140125790 - Device and method for three dimensional imaging of biological sample, published May 2014.
  • 20130189435 - Three-dimensional printing system using dual rotation axes, published July 2013.
  • 20130108014 - Method and apparatus for generating proton therapy treatment planning images, published May 2013.
  • 20100252728 - Mass spectrometer using an accelerating traveling wave, published October 2010.
Recent Publication(s)
  • Texture analysis applied to second harmonic generation image data for ovarian cancer classification. Wen BL, Brewer MA, Nadiarnykh O, Hocker J, Singh V, Mackie TR, Campagnola PJ. J Biomed Opt. 2014 Sep;19(9):096007. doi: 10.1117/1.JBO.19.9.096007.

  • The sweet spot: FDG and other 2-carbon glucose analogs for multi-modal metabolic imaging of tumor metabolism. Cox BL, Mackie TR, Eliceiri KW. Am J Nucl Med Mol Imaging. 2014 Dec 15;5(1):1-13. eCollection 2015. Review.

  • Automated quantification of aligned collagen for human breast carcinoma prognosis. Bredfeldt JS, Liu Y, Conklin MW, Keely PJ, Mackie TR, Eliceiri KW. J Pathol Inform. 2014 Aug 28;5(1):28. doi: 10.4103/2153-3539.139707. eCollection 2014.

  • Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer. Bredfeldt JS, Liu Y, Pehlke CA, Conklin MW, Szulczewski JM, Inman DR, Keely PJ, Nowak RD, Mackie TR, Eliceiri KW. J Biomed Opt. 2014 Jan;19(1):16007. doi: 10.1117/1.JBO.19.1.016007.

View T. Rockwell Mackie's publications at PubMed.
Recent Artistic Works
  • University of Colorado, Radiation Oncology
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-7358
Current University UW–Madison
Department Engineering Physics / Medical Physics
Title Emeritus Professor
Other Appointments
Director, Medical Devices Focus Area, Morgridge Institute for Research
Co-Founder and Chairman, TomoTherapy Inc.
Address Line 1 Engineering Research Building
Address Line 2 1500 Engineering Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., University of Saskatchewan, Physics, 1980
Master's Degree
PhD Ph.D., University of Alberta, Physics, 1984
Other Degrees
Technologies Available for Licensing Low Skin Dose Patient Positioning Device for Radiation Treatment of Prone Breast

High-Speed Computed Tomography System Using a Spherical Anode for Improved Medical Imaging

Scanning Aperture Ion Beam Range Compensator and Intensity Modulator for External Radiation Therapy

Distal Gradient Tracking (DGT) for Ion Beam Radiation Therapy

Ion Fan Beam Radiation Therapy System with Partial Arc Motion

Multi-Beamlet Resolution Proton Therapy (MBRPT) for Ion Beam Treatment of Tumors

Probabilistic Least Squares Optimization for Radiation Therapy to Remove Patient Motion Effects

Space and Time Variant Electric Field Enhancement Improves Accuracy of Mass Spectroscopy for Large Compounds

Quadrupole Magnetic Fan Beam Former for Ion Radiation Therapy Systems

Multi-Element Ion Beam Range and Intensity Modulator for Radiation Therapy

Monitoring Tissue Fluorescence in Bright Light

More Accurate Method for Generating Proton Therapy Treatment Planning Images

Producing Medical Isotopes with Dry-Phase Reactor

Radial 3-D Printer for Improved Prototyping Efficiency

Improved Proton-Based Cancer Radiation Therapy System with Beam Intensity and Energy Modulation