Wisconsin Discovery Portal

Researcher: Eric Shusta

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Areas of Expertise
  • Blood-brain barrier (BBB) engineering
  • Brain drug delivery
  • Non-invasive delivery methods
  • Treatment of neurological diseases
  • Novel transport systems and cognate antibody targeting molecules
  • Design of high throughput selections
  • Therapeutic antibodies and proteins
  • Drug discovery
  • Biopharmaceutical design
Web Site Eric Shusta's College of Engineering Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,754,193 - GFAbs: GFP-based biosensors possessing the binding properties of antibodies, issued June 2014.
  • 8,293,495 - Blood-brain barrier model, issued October 2012.
  • 8,034,607 - Methods of enhanced heterologous protein secretion , issued October 2011.
  • 7,981,417 - Blood-brain barrier targeting anti-bodies, issued July 2011.
  • 7,744,879 - Blood-brain barrier targeting antibodies, issued June 2010.
USPTO Published Applications
  • 20160122417 - Engineered intein for improved production of protein-intein fusions, published May 2016.
  • 20150196663 - Blood-brain barrier targeting antibodies, published July 2015.
  • 20140127800 - Retinoic acid enhanced human stem cell derived blood brain barrier model, published May 2014.
  • 20130029419 - Blood-brain barrier model, published January 2013.
  • 20120277122 - GFABS: GFP-based biosensors possessing the binding properties of antibodies, published November 2012.
Recent Publication(s)
  • Analysis of cancer-targeting alkylphosphocholine analogue permeability characteristics using a human induced pluripotent stem cell blood-brain barrier model. Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV. Mol Pharm. 2016 Sep 6;13(9):3341-9. doi: 10.1021/acs.molpharmaceut.6b00441. Epub 2016 Aug 4.

  • Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Stebbins MJ, Wilson HK, Canfield SG, Qian T, Palecek SP, Shusta EV. Methods. 2016 May 15;101:93-102. doi: 10.1016/j.ymeth.2015.10.016. Epub 2015 Oct 27.

  • In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. Helms HC, Abbott NJ, Burek M, Cecchelli R, Couraud PO, Deli MA, Förster C, Galla HJ, Romero IA, Shusta EV, Stebbins MJ, Vandenhaute E, Weksler B, Brodin B. J Cereb Blood Flow Metab. 2016 May;36(5):862-90. doi: 10.1177/0271678X16630991. Epub 2016 Feb 11. Review.

  • Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV. Biotechnol J. 2016 Mar;11(3):425-36. doi: 10.1002/biot.201500360. Epub 2015 Dec 9.
Recent Artistic Works
  • Biotechnology Training Program
  • Blood-Brain Barrier Group
  • Chemistry Biology Interface Training Program
  • Clinical Neuroengineering Training Program
  • University of Wisconsin Comprehensive Cancer Center
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-5103
Current University UW–Madison
Department Chemical and Biological Engineering
Title Professor
Other Appointments
Address Line 1 3631 Engineering Hall
Address Line 2 1415 Engineering Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., UW–Madison
Master's Degree M.S., University of Illinois-Urbana Champaign
PhD Ph.D., University of Illinois-Urbana Champaign
Other Degrees
Technologies Available for Licensing Blood-Brain Barrier Targeting Antibodies

Enhancing the Production of Foreign Proteins in Yeast by Overexpressing Endogenous Genes

Blood-Brain Barrier Targeting Antibodies to Improve Drug Delivery

GFAbs – GFP-Based Biosensors with the Binding Properties of Antibodies

Improved Method to Produce Brain Microvascular Endothelial Cells for a Robust Human Blood-Brain Barrier Model

Enhanced Blood-Brain Barrier Model Outperforms All Others