Wisconsin Discovery Portal

Researcher: Jonathan Makielski

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Areas of Expertise
  • Cardiovascular medicine
  • Molecular electrophysiology
  • Cardiac ion channels
Web Site Jonathan Makielski's Department of Medicine Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 7,485,455 - Nucleic acid encoding sodium channel subunit, issued February 2009.
USPTO Published Applications
  • 20080293087 - Sulfonylurea receptor short forms from mitochondria and uses thereof, published November 2008.
  • 20040126787 - Sodium channel alpha subunit variants, published July 2004.
  • 20030157600 - Sodium channel alpha subunits, published August 2003.
Recent Publication(s)
  • Ik1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: An improved cardiomyocyte model to investigate inherited arrhythmia syndromes. Vaidyanathan R, Markandeya YS, Kamp TJ,┬áMakielski JC, January CT, Eckhardt LL. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1611-21. doi: 10.1152/ajpheart.00481.2015. Epub 2016 Apr 8.

  • The biophysical characterization of the first scn5a mutation r1512w identified in chinese sudden unexplained nocturnal death syndrome. Zheng J, Zhou F, Su T, Huang L, Wu Y, Yin K, Wu Q, Tang S,┬áMakielski JC, Cheng J. Medicine (Baltimore). 2016 Jun;95(23):e3836. doi: 10.1097/MD.0000000000003836.

  • Identification of rare variants of dsp gene in sudden unexplained nocturnal death syndrome in the southern chinese han population. Zhao Q, Chen Y, Peng L, Gao R, Liu N, Jiang P, Liu C, Tang S, Quan L,Makielski JC, Cheng J. Int J Legal Med. 2016 Mar;130(2):317-22. doi: 10.1007/s00414-015-1275-2. Epub 2015 Nov 19.

  • Late sodium current: A mechanism for angina, heart failure, and arrhythmia. Makielski JC. Trends Cardiovasc Med. 2016 Feb;26(2):115-22. doi: 10.1016/j.tcm.2015.05.006. Epub 2015 May 22. Review.

View Jonathan Makielski's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Physiology, Stem Cell and Regenerative Medicine Center
  • University of California-Berkeley, Bioengineering, Material Science and Engineering
  • University of California-San Francisco, Medicine, Anatomy, Cellular and Molecular Pharmacology
  • University of Tampere, Institute of Biomedical Technology
  • Kyoto University, Center for iPS Cell Research and Application
  • University of Chicago, Human Genetics
  • Mayo Clinic, Molecular Pharmacology, Pediatric Cardiology, Medicine
  • Guangzhou Institute of Forensic Science
  • Sun Yat-sen University, Forensic Pathology
  • Gladstone Institute of Cardiovascular Disease
  • Baylor College of Medicine
Research Tools
Research Facilities
  • Cellular and Molecular Arrhythmia Research Program (CMARP)
E-mail Address [email protected]
Phone Number 608-263-2048
Current University UW–Madison
Department Medicine
Title Professor
Other Appointments
Address Line 1 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree
Master's Degree
Other Degrees M.D., University of Chicago
Technologies Available for Licensing Cell Line Stably Expressing the Human Heart Sodium Channel Beta1 Subunit

Human Heart Sodium Channel Beta1 Subunit (SCNB1)

Common Variants of the Sodium Channel Alpha Subunits

Antibody That Recognizes the Sulfonylurea Receptor 1 Isoform

New Cell Lines Containing Stably Expressed KATP Pores for High Throughput Screening

Antibody That Recognizes the Sulfonylurea Receptor 2 Isoform

Antibody That Recognizes Both Isoforms of the Sulfonylurea Receptor

Antibody That Recognizes the 2A Variant of the Sulfonylurea Receptor

Antibody That Recognizes the 2B Variant of the Sulfonylurea Receptor