Wisconsin Discovery Portal

Researcher: Paul Ahlquist

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Areas of Expertise
  • Molecular mechanisms of viral replication
  • Host interactions and oncogenesis for selected RNA
  • DNA and reverse-transcribing viruses, including several human tumor viruses
  • Positive strand RNA viruses
  • Higher eukaryotic viruses that can direct genome replication, gene expression, and virion assembly in the genetically tractable yeast Saccharomyces cerevisiae
Web Site Paul Ahlquist's University Web Page
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,012,678 - Biomarkers for human papilloma virus-associated cancer, issued September 2011.
  • 7,611,833 - Yeast genes that affect viral replication, issued November 2009.
  • 7,563,597 - Production of packaged DNA sequences, issued July 2009.
  • 6,291,743 - Transgenic plants expressing mutant geminivirus AC1 or C1 genes, issued September 2001.
  • 5,869,287 - Method of producing particles containing nucleic acid sequences in yeast, issued February 1999.
USPTO Published Applications
  • 20110301059 - Biomarkers for human papilloma virus-associated cancers, published December 2011.
  • 20110189258 - Method and compositions for inhibition of double stranded DNA viruses, published August 2011.
Recent Publication(s)
  • Host ESCRT proteins are required for bromovirus RNA replication compartment assembly and function. Diaz A, Zhang J, Ollwerther A, Wang X, Ahlquist P. PLoS Pathog. 2015 March 6;11(3):e1004742. doi: 10.1371/journal.ppat.1004742. eCollection 2015.
  • Sulfonation pathway inhibitors block reactivation of latent HIV-1. Murry JP, Godoy J, Mukim A, Swann J, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina CA, Young JA. Virology. 2014 Dec;471-473:1-12. doi: 10.1016/j.virol.2014.08.016. Epub 2014 Oct 11. Virology. 2014 December;471-473:1-12. doi: 10.1016/j.virol.2014.08.016. Epub 2014 October 11.
  • Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism. Aligeti M, Behrens RT, Pocock GM, Schindelin J, Dietz C, Eliceiri KW, Swanson CM, Malim MH, Ahlquist P, Sherer NM. J Virol. 2014 December;88(24):14207-14221. doi: 10.1128/JVI.01897-14. Epub 2014 October 1.
  • Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly. Shen QT, Schuh AL, Zheng Y, Quinney K, Wang L, Hanna M, Mitchell JC, Otegui MS, Ahlquist P, Cui Q, Audhya A. J Cell Biol. 2014 September 15;206(6):763-777. doi: 10.1083/jcb.201403108. Epub 2014 September 8.

View Paul Ahlquist's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Statistics, Biostatistics and Medical Informatics, Biomolecular Chemistry, Botany, Genetics, Chemistry, Mathematics, Biochemistry, Morgridge Institute for Research, Laboratory for Optical and Computational Instrumentation
  • National Cancer Institute, NIH, Bethesda
  • University of California, San Diego, Pathology, National Center for Microscopy and Imaging Research
  • Virginia Tech University, Plant Pathology, Physiology, and Weed Science
  • University of Utah, Pathology
  • University of Constance, Computer and Information Science
  • King's College London, Infectious Diseases
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-5916
Current University UW–Madison
Department Oncology / Molecular Virology / Plant Pathology
Title Professor
Other Appointments Investigator, Howard Hughes Medical Institute
Address Line 1 841A Bock Laboratories
Address Line 2 1525 Linden Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Iowa State University, Physics, 1976
Master's Degree
PhD Ph.D., UW–Madison, Biophysics, 1981
Other Degrees
Technologies Available for Licensing