Wisconsin Discovery Portal

Researcher: Christopher Bradfield

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Areas of Expertise
  • Molecular biology of the PAS family of proteins
  • Family of transcriptional regulators known as PAS proteins
  • Characterization of the Ah-receptor/Arnt pathway in genetically manipulable organisms such as mice and yeast
  • Biological adaptation to environmental stress and carcinogen exposure
Web Site Christopher Bradfield's Department of McArdle Laboratory for Cancer Research Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 7,501,489 - cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use, issued March 2009.
  • 7,105,647 - cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use, issued September 2006.
  • 6,432,692 - Sensitive bioassay for detecting agonists of the aryl hydrocarbon receptor, issued August 2002.
USPTO Published Applications
  • 20140050694 - Method of treating transplant rejection and autoimmune diseases, published February 2014.
  • 20060084798 - cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use, published April 2006.
Recent Publication(s)
  • Global and hepatocyte-specific ablation of bmal1 induces hyperlipidaemia and enhances atherosclerosis. Pan X, Bradfield CA, Hussain MM. Nat Commun. 2016 Oct 10;7:13011. doi: 10.1038/ncomms13011.

  • The aryl hydrocarbon receptor is a repressor of inflammation-associated colorectal tumorigenesis in mouse. Díaz-Díaz CJ, Ronnekleiv-Kelly SM, Nukaya M, Geiger PG, Balbo S, Dator R, Megna BW, Carney PR, Bradfield CA, Kennedy GD. Ann Surg. 2016 Sep;264(3):429-36. doi: 10.1097/SLA.0000000000001874.

  • Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in csrp2bp, dzank1, and ovol2 gene expression. Shen AL, Moran SA, Glover EA, Drinkwater NR, Swearingen RE, Teixeira LB,Bradfield CA. PLoS One. 2016 Jun 16;11(6):e0157577. doi: 10.1371/journal.pone.0157577. eCollection 2016.

  • Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Perelis M, Marcheva B, Ramsey KM, Schipma MJ, Hutchison AL, Taguchi A, Peek CB, Hong H, Huang W, Omura C, Allred AL, Bradfield CA, Dinner AR, Barish GD, Bass J. Science. 2015 Nov 6;350(6261):aac4250. doi: 10.1126/science.aac4250.

View Christopher Bradfield's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Surgery, Comparative Biosciences
  • University of Texas Southwestern Medical Center, Neuroscience
  • Northwestern University, Neurobiology, Molecular Biosciences, Howard Hughes Medical Institute
  • Harbor-University of California Los Angeles Medical Center, National Hormone and Peptide Program
  • University of Tübingen, Werner Reichardt Centre for Integrative Neuroscience
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-2024
Current University UW–Madison
Department Oncology / Wisconsin Institute for Discovery
Title Professor
Other Appointments Academic Program Director
Address Line 1 Discovery Building
Address Line 2 330 North Orchard Street
City Madison
State WI
Zip Code 53715
Bachelor's Degree B.S., University of California at Davis, Environmental Toxicology, 1982
Master's Degree
PhD Ph.D., University of California at Berkeley, Toxicology and Nutrition, 1986
Other Degrees
Technologies Available for Licensing Unique, Full-Length Mouse cDNAs

Mouse Expressed Sequence Tags Related to Liver, Skin, Kidney, Thymus, Lung and Palate Toxicology

Genetically Modified Mouse Model Displaying Abnormalities in Circadian Rhythms

Controllable Murine Models of First Pass Metabolism

Full-Length cDNA Libraries from Dioxin- and Vehicle-Treated Mice

Sensitive Bioassay for Detecting Dioxins and PCBs