Wisconsin Discovery Portal

Researcher: Edwin Chapman

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Areas of Expertise
  • Medicine
  • Public health
  • Ion channels
  • Synaptic transmission
  • Neural development
  • Sensory and cognitive physiology
  • Neural circuits
  • Neuro
  • Nanomechanics of Ca2+-triggered membrane fusion. 
  • Probing the structure and dynamics of fusion pores
  • Basic synaptic properties to aspects of network-level function and plasticity
  • Elucidation of the receptors, entry pathways, and the molecular basis for translocation across membranes, of botulinum (BoNT) and tetanus neurotoxins (TeNT)
  • Molecular mechanisms regulating organelle distribution and homeostasis in mammalian neurons
  • Role of synaptotagmins in hormone secretion in the pituitary
Web Site Edwin Chapman's Department of Neuroscience Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,999,649 - Method and compositions for detecting botulinum neurotoxin, issued April 2015.
  • 8,987,208 - Botulinum neurotoxin a receptor and the use thereof, issued March 2015.
  • 8,771,707 - Botulinum neurotoxin E receptors and uses thereof, issued July 2014.
  • 8,617,573 - Botulinum neurotoxin B receptors and use thereof, issued December 2013.
  • 8,450,277 - Methods for reducing botulinum neurotoxin A toxicity, issued May 2013.
USPTO Published Applications
  • 20150283261 - Method for selective targeting and entry of bacterial toxins to cells, published October 2015.
  • 20150253326 - Methods and compositions for detecting botulinum neurotoxin, published September 2015.
  • 20140322730 - Botulinum neurotoxin E receptors and uses thereof, published October 2014.
  • 20140017251 - Botulinum neurotoxin A receptors and uses thereof, published January 2014.
Recent Publication(s)
  • Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1. Evans CS, He Z, Bai H, Lou X, Jeggle P, Sutton RB, Edwardson JM, Chapman ER. Mol Biol Cell. 2016 Mar 15;27(6):979-89. doi: 10.1091/mbc.E15-07-0503. Epub 2016 Jan 20.

  • Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion. Chang CW, Chiang CW, Gaffaney JD, Chapman ER, Jackson MB. J Biol Chem. 2016 Feb 5;291(6):2848-57. doi: 10.1074/jbc.M115.701169. Epub 2015 Dec 8.

  • Exocytotic fusion pores are composed of both lipids and proteins. Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM, Chapman ER. Nat Struct Mol Biol. 2016 Jan;23(1):67-73. doi: 10.1038/nsmb.3141. Epub 2015 Dec 14.

  • Sar1 GTPase Activity Is Regulated by Membrane Curvature. Hanna MG 4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. J Biol Chem. 2016 Jan 15;291(3):1014-27. doi: 10.1074/jbc.M115.672287. Epub 2015 Nov 6.

View Edwin Chapman's publications at PubMed.
Recent Artistic Works
  • Yale University
  • University of California Riverside
  • Howard Hughes Medical Institute
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-1762
Current University UW–Madison
Department Physiology
Title Professor
Other Appointments
Investigator, Howard Hughes Medical Institute
Address Line 1 203 Service Memorial Institute
Address Line 2 470 North Charter Street
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Chemistry and Biology, Western Washingtion University
Master's Degree
PhD Ph.D., University of Washington
Other Degrees
Technologies Available for Licensing Method and Compositions for Detecting Botulinum Neurotoxin

Protein Receptors for Botulinum Neurotoxin E (BoNT/E) Enable Means of Reducing BoNT/E Toxicity