Wisconsin Discovery Portal

Researcher: Richard Moss

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Areas of Expertise
  • Molecular and cellular biology
  • Pharmacology
  • Cardiovascular biology
  • Developmental biology
  • Stem cell and regenerative biology
  • Heart and skeletal muscle physiology
  • Contractile processes in heart and skeletal muscles
  • Alterations in contraction in diseases such as heart failure
  • Mechanisms by which calcium, various physical factors, and signal transduction pathways regulate myocardial contraction
Web Site Richard Moss' Department of Cell and Regenerative Biology Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 9,051,387 - Inhibition of mybp-c binding to myosin as a treatment for heart failure, issued June 2015.
  • 7,276,644 - Transgenic mouse comprising a myosin heavy chain atpase loop 1 mutation, issued October 2007.
  • 5,700,790 - Prevention and treatment of myocardial failure, issued December 1997.
USPTO Published Applications
Recent Publication(s)
  • Phosphorylation of cardiac myosin binding protein c releases myosin heads from the surface of cardiac thick filaments. Kensler RW, Craig R, Moss RL. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1355-E1364. doi: 10.1073/pnas.1614020114. Epub 2017 Feb 6.


  • Top-down targeted proteomics reveals decrease in myosin regulatory light-chain phosphorylation that contributes to sarcopenic muscle dysfunction. Gregorich ZR, Peng Y, Cai W, Jin Y, Wei L, Chen AJ, McKiernan SH, Aiken JM,┬áMoss RL, Diffee GM, Ge Y. J Proteome Res. 2016 Aug 5;15(8):2706-16. doi: 10.1021/acs.jproteome.6b00244. Epub 2016 Jul 13.

  • Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase. Massengill MT, Ashraf HM, Chowdhury RR, Chrzanowski SM, Kar J, Warren SA, Walter GA, Zeng H, Kang BH, Anderson RH,┬áMoss RL, Kasahara H. Cardiovasc Res. 2016 Jul 1;111(1):34-43. doi: 10.1093/cvr/cvw069. Epub 2016 Mar 29.

  • Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove. Moss RL. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3133-5. doi: 10.1073/pnas.1602568113. Epub 2016 Mar 10. No abstract available.
Recent Artistic Works
Collaboration
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-0523
Current University UW–Madison
Department Cell and Regenerative Biology / Administration
Title Professor
Other Appointments Associate Dean
Address Line 1 4111A Health Sciences Learning Center
Address Line 2 750 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree
Master's Degree
PhD Ph.D., University of Vermont, 1975
Other Degrees
Technologies Available for Licensing Open-Chested Animal Teaching Video of Myocardial Infarction

Treating Heart Failure by Inhibiting Myosin Interaction with a Regulatory Myosin Binding Protein