Wisconsin Discovery Portal

Researcher: Daniel Greenspan

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Areas of Expertise
  • Extracellular controls of cell behavior in development, homeostasis, and disease
  • Genes and gene products important to vertebrate development and human disease
  • Extracellular regulatory molecules that control and orchestrate events as diverse as signaling by growth factors and formation of the extracellular matrix
  • Roles of extracellular proteins in adipocyte biology, diabetic symptoms, atherosclerosis, and organ transplant rejection
Web Site Daniel Greenspan's University Web page
Curriculum Vitae (CV)
Issued Patent(s)
  • 7,888,313 - Composition for treating a fibrotic disorder comprising an inhibitor of a BMP-1-like protein, issued February 2011.
  • 7,572,599 - Metalloprotease activation of myostatin, and methods of modulating myostatin activity, issued August 2009.
  • 6,759,528 - Mammalian pro-.alpha.3(V) collagen chain genes, issued July 2004.
  • 6,297,011 - Mammalian tolloid-like gene and protein, issued October 2001.
  • 6,037,139 - System for assaying modulators of procollagen maturation, issued March 2000.
USPTO Published Applications
Recent Publication(s)
  • Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice. Muir AM, Ren Y, Butz DH, Davis NA, Blank RD, Birk DE, Lee SJ, Rowe D, Feng JQ, Greenspan DS. Hum Mol Genet. 2014 June 15;23(12):3085-3101. doi: 10.1093/hmg/ddu013. Epub 2014 January 12.
  • IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis. Vittal R, Fan L, Greenspan DS, Mickler EA, Gopalakrishnan B, Gu H, Benson HL, Zhang C, Burlingham W, Cummings OW, Wilkes DS. Am J Physiol Lung Cell Mol Physiol. 2013 March 15;304(6):L401-414. doi: 10.1152/ajplung.00080.2012. Epub 2012 December 21.
  • Comprehensive mass spectrometric mapping of the hydroxylated amino acid residues of the α1(V) collagen chain. Yang C, Park AC, Davis NA, Russell JD, Kim B, Brand DD, Lawrence MJ, Ge Y, Westphall MS, Coon JJ, Greenspan DS. J Biol Chem. 2012 November 23;287(48):40598-40610. doi: 10.1074/jbc.M112.406850. Epub 2012 October 11.
  • Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish. Asharani PV, Keupp K, Semler O, Wang W, Li Y, Thiele H, Yigit G, Pohl E, Becker J, Frommolt P, Sonntag C, Altmüller J, Zimmermann K, Greenspan DS, Akarsu NA, Netzer C, Schönau E, Wirth R, Hammerschmidt M, Nürnberg P, Wollnik B, Carney TJ. Am J Hum Genet. 2012 April 6;90(4):661-674. doi: 10.1016/j.ajhg.2012.02.026.
Recent Artistic Works
Collaboration
  • Intra-University Collaboration: Chemistry, Medicine
  • Indiana University, Center for Immunobiology
  • Institute of Molecular and Cell Biology, Proteos, Singapore
  • Baylor College, Biomedical Sciences
  • University of South Florida, Pharmacology and Physiology
  • Johns Hopkins University, Molecular Biology and Genetics
  • University of Connecticut, Reconstructive Sciences
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-4676
Current University UW–Madison
Department Cell and Regenerative Biology
Title Professor
Other Appointments
Address Line 1 4503 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.A., New York University
Master's Degree
PhD Ph.D., New York University, 1981
Other Degrees
Technologies Available for Licensing Bone Morphogenetic Protein-1 Biological Materials

Treating Fibrotic Disorders by Inhibiting BMP-1-Like Proteinases