Wisconsin Discovery Portal

Researcher: Brian Pfleger

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Areas of Expertise
  • Bioscience and engineering
  • Metabolic engineering
  • Biotechnology
  • Synthetic biology
  • Natural products
  • Protein engineering
  • Cyanobacteria
  • Sustainability
Web Site Brian Pfleger's Department of Chemical and Biological Engineering Website
Curriculum Vitae (CV)
Issued Patent(s)
  • 8,617,856 - Fatty acid-producing hosts, issued December 2013.
  • 8,114,645 - Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels, issued February 2012.
USPTO Published Applications
  • 20110165637 - Fatty acid-producing hosts, published July 2011.
  • 20100055754 - Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels, published March 2010.
Recent Publication(s)
  • Microbes paired for biological gas-to-liquids (Bio-GTL) process. Pfleger BF. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3717-9. doi: 10.1073/pnas.1601926113. Epub 2016 Mar 16. No abstract available.

  • A transcription activator-like effector (TALE) induction system mediated by proteolysis. Copeland MF, Politz MC, Johnson CB, Markley AL, Pfleger BF. Nat Chem Biol. 2016 Apr;12(4):254-60. doi: 10.1038/nchembio.2021. Epub 2016 Feb 8.

  • Biological synthesis unbounded? Pfleger BF, Prather KL. Nat Biotechnol. 2015 Nov;33(11):1148-9. doi: 10.1038/nbt.3399. No abstract available.

  • Efflux systems in bacteria and their metabolic engineering applications. Jones CM, Hernández Lozada NJ, Pfleger BF. Appl Microbiol Biotechnol. 2015 Nov;99(22):9381-93. doi: 10.1007/s00253-015-6963-9. Epub 2015 Sep 12.

View Brian Pfleger's publications at Google Scholar.
Recent Artistic Works
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-890-1940
Current University UW–Madison
Department Chemical and Biological Engineering
Title Jay and Cynthia Ihlenfeld Professor
Other Appointments
Address Line 1 3629 Engineering Hall
Address Line 2 1415 Engineering Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Cornell University, Chemical Engineering, 2000
Master's Degree
PhD Ph.D., University of California-Berkeley, Chemical Engineering, 2005
Other Degrees
Technologies Available for Licensing Modified Microbes Tolerate 50-Fold More Organic Acid

Microbes Produce High Yields of Fatty Alcohols from Glucose

Translation-Coupling Cassette for Quickly and Reliably Monitoring Protein Translation in Host Cells

Fatty Acid-Producing Microbes for Generating Medium- and Long-Chain Hydrocarbons