Researcher: Douglas Weibel

Areas of Research Expertise
  • Cellular regulation
  • Molecular genetics
  • Protein structure
  • Hormone action
  • Cell biology
  • Structure, function, and behavior of bacteria
  • Bacterial processes
  • Cell division
  • Membrane organization
  • Cell wall assembly
  • Chemotaxis
  • Cell motility
  • Components of cellular processes using a genome-wide strategy
  • Chemical language of bacterial chemoreceptors
  • Molecular diagnostics for detecting bacterial infections
  • Biomolecular regulation of bacterial mechanics
  • Antibiotics
  • Clinical trials on pre-term infants to reduce the rates of harmful bacterial infections
Web Site Douglas Weibel's Department of Biochemistry Website
Curriculum Vitae (CV)
Current/Active Funding
  • Dreyfus (Camile & Henry) Foundation, In, 2010-2018, Special grant program in the chemical science
  • EI Du Pont De Nemours and Company, 2010-2019, Dupont young professor program 2010-2012
  • International Human Frontier Science Pro, 2013-2017, Characterizing new components of the bacterial cytoskeleton
  • Gates (Bill and Melinda) Foundation, 2014-2017, Diagnostics for the control and eradication of diseases in plants and livestock
  • WARF, 2013-2020, Doug weibel patent income
  • NIH, 2015-2017, Early diagnosis of neonatal infections using urine metabolomics
  • L'Oreal Group, 2014-2016, Early diagnosis of neonatal infections using urine metabolomics
  • Hatch Act Formula Fund, 2016-2020, Developing 'new' antibiotics against 'old' drug targets (wis01942)
  • Gates (Bill and Melinda) Foundation, 2016-2017, Editing the newborn gut microbiome using engineered bacteriophage
  • WARF, 2015-2016, Discovery challenge_stilwell
Issued Patent(s)
  • 9,289,123 - Contact lens for measuring intraocular pressure, issued March 2016.
  • 9,282,738 - Antimicrobial compositions and methods of use thereof, issued March 2016.
  • 9,101,309 - Method and system for measuring retinal, issued August 2015.
  • 9,050,593 - Self-loading microfluidic device and methods of use, issued June 2015.
  • 8,486,833 - Fabrication of conductive pathways, microcircuits and microstructures in microfluidic networks, issued July 2013.
USPTO Published Applications
  • 20160175287 - Antimicrobial compositions and methods of use thereof, published June 2016.
  • 20160002163 - Antimicrobial compounds, compositions and methods of use thereof, published January 2016.
  • 20150321194 - Self-loading microfluidic device and methods of use, published November 2015.
  • 20150164321 - Contact lens for measuring intraocular pressure, published June 2015.
  • 20130331424 - Antimicrobial compounds, compositions and methods of use thereof, published December 2013.
Recent Publication(s)
  • Mechanical genomics identifies diverse modulators of bacterial cell stiffness. Auer GK, Lee TK, Rajendram M, Cesar S, Miguel A, Huang KC, Weibel DB. Cell Syst. 2016 Jun 22;2(6):402-11. doi: 10.1016/j.cels.2016.05.006. Epub 2016 Jun 16.

  • Straining soft colloids in aqueous nematic liquid crystals. Mushenheim PC, Pendery JS, Weibel DB, Spagnolie SE, Abbott NL. Proc Natl Acad Sci U S A. 2016 May 17;113(20):5564-9. doi: 10.1073/pnas.1600836113. Epub 2016 May 2.

  • Ionic hydrogen bonds and lipid packing defects determine the binding orientation and insertion depth of reca on multicomponent lipid bilayers. Zhang L, Rajendram M, Weibel DB, Yethiraj A, Cui Q. J Phys Chem B. 2016 May 2. [Epub ahead of print]

  • Organization and function of anionic phospholipids in bacteria. Lin TY, Weibel DB. Appl Microbiol Biotechnol. 2016 May;100(10):4255-67. doi: 10.1007/s00253-016-7468-x. Epub 2016 Mar 30. Review.

View Douglas Weibel's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Chemistry, Medical Microbiology, Chemical and Biological Engineering
  • Yale University, Molecular Cellular & Developmental Biology, Medicine, Microbial Pathogenesis, Howard Hughes Medical Institute
  • California Institute of Technology
  • University of California-San Francisco
  • University of Tokyo
  • Lehigh University
  • Washington University
  • Polish Academy of Sciences
  • Princeton University
  • Max Planck Institute
  • University of Newcastle (England), Medicine, Cell & Molecular Bioscience
  • Uppsala University (Sweden), Cell & Molecular Biology
Research Tools
  • High-Resolution Microscopy
  • Mass Spectrometry
  • Photolithography Tools
  • RIE
  • Bonding Equipment
Research Facilities
  • The Weibel Lab
  • Biotechnology Center
  • Biophysics Instrumentation Facility
  • Wisconsin Center for Applied Microelectronics
E-mail Address [email protected]
Phone Number 608-890-1342
Current University UW–Madison
Department Biochemistry
Title Associate Professor
Other Appointments
Address Line 1 471C DeLuca Biochemistry Laboratories
Address Line 2 433 Babcock Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., University of Utah, Chemistry, 1996
Master's Degree M.S., Cornell University, Organic Chemistry, 1999
PhD Ph.D., Cornell University, Organic Chemistry, 2002
Other Degrees Postdoc, Harvard University
Technologies Available for Licensing New Broad-Spectrum Antibiotics

Improved Self-Loading Microfluidic Device for Determining Effective Antibiotic Dose and Other Chemical and Biological Assays

New Antimicrobials for Treating Bacterial Infection and Contamination

A Novel Series of Antimicrobials Target Bacteria Membranes to Overcome Antibiotic Resistance