Researcher: Su-Chun Zhang

Areas of Research Expertise
  • Medicine
  • Public health
  • Ion channels
  • Synaptic transmission
  • Neural development
  • Sensory and cognitive physiology
  • Neural circuits
  • Neuro
  • Neuronal and glial subtypes
  • Neural differentiation
  • Induction of multipotential neuroepithelial cells
  • Pattern of region-specific neural progenitors
  • Generation of neurons and glia with particular transmitter or functional phenotypes
Web Site Su-Chun Zhang's Department of Waisman Center Website
Curriculum Vitae (CV)
Current/Active Funding
  • NIH, 2012-2017, Individualized cell therapy fo Parkinson's disease
  • NIH, 2013-2016, Development and function of human astrocytes
  • WARF, 2012-2020, Laboratory share - Zhang
  • Texas A&M University Health Science Ctr, 2014-2016, Human iPSC-derived GABA-ergic precursor cell therapy for chronic epilepsy
  • Amytrophic Lateral Sclerosis (ALS) ASSO, 2014-2017, Identifying drugs that restore NF levels and inhibit NF aggregation in ALS patient motor neurons
Issued Patent(s)
  • 9,080,151 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells, issued July 2015.
  • 8,895,302 - Directed differentiation of primate pluripotent stem cells into functional basal forebrain cholinergic neurons (BFCNs) and medium spiny gabaergic projection neurons, issued November 2014.
  • 8,895,301 - Exogenous Pax6 nucleic acid expression in primate neural stem cells maintains proliferation without differentiation, issued November 2014.
  • 8,658,424 - Myelinating oligodendrocyte precursor populations, issued February 2014.
  • 8,597,945 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells, issued December 2013.
USPTO Published Applications
  • 20150285822 - Therapeutic and diagnostic methods and compositions for neurodegenerative diseases, published October 2015.
  • 20140248696 - Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors, published September 2014.
  • 20130011917 - Method of generating myelinating oligodendrocytes, published January 2013.
  • 20120184032 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells, published July 2012.
Recent Publication(s)
  • Generation of serotonin neurons from human pluripotent stem cells. Lu J, Zhong X, Liu H, Hao L, Huang CT, Sherafat MA, Jones J, Ayala M, Li L, Zhang SC. Nat Biotechnol. 2016 Jan;34(1):89-94. doi: 10.1038/nbt.3435. Epub 2015 Dec 14.

  • Illuminating Parkinson's therapy with optogenetics. Chen Y, Xiong M, Zhang SC. Nat Biotechnol. 2015 Feb;33(2):149-50. doi: 10.1038/nbt.3140.

  • The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism. Li M, Pehar M, Liu Y, Bhattacharyya A, Zhang SC, O'Riordan KJ, Burger C, D'Adamio L, Puglielli L. Neurobiol Aging. 2015 Oct;36(10):2725-36. doi: 10.1016/j.neurobiolaging.2015.06.021. Epub 2015 Jun 21.

  • Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9. Chen Y, Cao J, Xiong M, Petersen AJ, Dong Y, Tao Y, Huang CT, Du Z,Zhang SC.Cell Stem Cell. 2015 Aug 6;17(2):233-44. doi: 10.1016/j.stem.2015.06.001. Epub 2015 Jul 2.

View Su-Chun Zhang's publications at PubMed.
Recent Artistic Works
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-2543
Current University UW–Madison
Department Anatomy / Neurology
Title Professor
Other Appointments
Address Line 1 T-613 Waisman Center
Address Line 2 1500 Highland Avenue
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.S., Wenzhou Medical College
Master's Degree M.S., Shanghai Medical University
PhD Ph.D., University of Saskatchewan
Other Degrees M.D., Wenzhou Medical College
Technologies Available for Licensing Differentiation and Purification of Neural Precursors from Human Embryonic Stem Cells

In Vitro Differentiation of Neural Stem Cells and Neurons from Human Embryonic Stem Cells

Master Human Stem Cell Lines for Gene Expression and Knockdown

Generating Oligodendrocytes from Human Embryonic Stem Cells

New Target for Diagnosing, Treating Neurodegenerative Diseases