Researcher: Caroline Alexander

Areas of Research Expertise
  • Human tumors
  • Prevention
  • Diagnosis
  • Prognosis
  • Epstein-Barr viurs
  • Kaposi's sarcoma-associated herpes virus
  • Human cytomegalovirus
  • Human papillomaviruses
  • Hepatitis B virus
  • Mammary stem cells
  • Mouse mammary tumor models
  • Wnt signaling
  • Syndecan-1
  • Mammary gland biology and neoplasia
  • Recruitment of adult somatic stem cells as tumor precursor cells
  • Tumor resistance phenotype in mice
  • Stem cell-based breast cancer
  • Activation and recruitment of stromal cells
  • Adult stem cell responses during tumor initiation
  • Cell-cell interactions in the mammary gland
Web Site Caroline Alexander's Department of McArdle Laboratory for Cancer Research Website
Curriculum Vitae (CV)
Current/Active Funding
  • NIH, 2011-2017, Molecular and cellular mechanisms of tumor development
  • NIH, 2011-2017, Prolactin: Mammary progenitors and tumor initiating cells in luminal carcinomas
  • WARF, 2013-2020, Lab share of royalty and licensing - Caroline Alexander
Issued Patent(s)
  • 8,124,410 - Methods of finding, selecting and studying cells in heterogeneous co-cultures, issued February 2012.
  • 7,563,619 - Mammary stem cell marker, issued July 2009.
USPTO Published Applications
  • 20070287178 - Methods of finding, selecting and studying cells in heterogeneous co-cultures, published December 2007.
  • 20070280948 - Mammary stem cell marker, published December 2007.
Recent Publication(s)
  • Decreased consumption of branched-chain amino acids improves metabolic health. Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ,¬†Alexander CM, Kimple ME, Lamming DW. Cell Rep. 2016 Jul 12;16(2):520-30. doi: 10.1016/j.celrep.2016.05.092. Epub 2016 Jun 23.

  • Lrp5 has a wnt-independent role in glucose uptake and growth for mammary epithelial cells. Chin EN, Martin JA, Kim S, Fakhraldeen SA,¬†Alexander CM. Mol Cell Biol. 2015 Dec 28;36(6):871-85. doi: 10.1128/MCB.00800-15.

  • Dermal white adipose tissue: A new component of the thermogenic response. Alexander CM, Kasza I, Yen CL, Reeder SB, Hernando D, Gallo RL, Jahoda CA, Horsley V, MacDougald OA. J Lipid Res. 2015 Nov;56(11):2061-9. doi: 10.1194/jlr.R062893. Epub 2015 Sep 24.

  • Apoptosis-induced cancer cell fusion: A mechanism of breast cancer metastasis. Noubissi FK, Harkness T,¬†Alexander CM, Ogle BM. FASEB J. 2015 Sep;29(9):4036-45. doi: 10.1096/fj.15-271098. Epub 2015 Jun 17.

View Caroline Alexander's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Statistics, Biostatistics and Medical Informatics, Cell and Regenerative Biology, Dermatology, Neuroscience, Mechanical Engineering, Nutritional Sciences
  • University of Toronto, Ontario Cancer Institute
  • University of Michigan, Molecular and Integrative Physiology
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-5182
Current University UW–Madison
Department Oncology
Title Professor
Other Appointments
Address Line 1 6505 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.S., University of Aberdeen, Biochemistry, 1982
Master's Degree
PhD Ph.D., University of Kent, Cell Biology and Biochemistry, 1985
Other Degrees
Technologies Available for Licensing Methods of Finding, Selecting and Studying Cells in Heterogeneous Co-Cultures

Stem Cell Marker for Breast Cancer