Researcher: Bruce Klein

Areas of Research Expertise
  • Bacterial pathogensis
  • Immunology
  • Fungal pathpgenesis
  • Parasitology
  • Symbiosos
  • Virology
  • E. coli
  • Infectious disease
  • Molecular medical mycology
  • Cellular and molecular basis of immunity to medical fungi
  • Genetics of virulence
  • Molecular mechanisms of pathogenesis
Web Site Bruce Klein's Department of Medical Microbiology and Immunology Website
Curriculum Vitae (CV)
Current/Active Funding
  • WARF, 2002-2020, Laboratory share of royalty and licensing - Professor Bruce S. Klein
  • NIH, 2014-2019, T32 - Microbes in Health and Disease
  • Pediatric Infectious Diseases Society, 2014-2017, Understanding fungal morphogenesis and dissemination using in vivo imaging of a larval zebrafish model (J. M. Davis) Fellowship
  • NIH, 2014-2016, Molecular pathogenesis and Blastomyces adherence
  • Interior, US Geological Survey, 2014-2017, Oral vaccines and delivery methods for controlling diseases in bats
  • NIH, 2015-2019, Molecular pathogenesis of Blastomycosis
  • NIH, 2015-2016, Role of airway epithelial cells in host defense against pulmonary fungal pathogens (Hernandez-Santos F32)
  • WARF, 2015-2017, Microbes in health and disease
  • The Hartwell Foundation, 2015-2017, Hartwell post-doctoral fellowship, Darin Wiesner "elucidating the induction of allergic asthma by the pulmonary epithelium"
  • NIH, 2016-2017, Mechanisms of anti-fungal vaccine immunity (renewal resub)
Issued Patent(s)
  • 7,888,120 - Global regulator of morphogenesis and pathogenicity in dimorphic fungi and uses thereof, issued February 2011.
  • 6,248,322 - Attenuated vaccine for Blastomyces dermatitidis, issued June 2001.
USPTO Published Applications
  • 20150301044 - Peptide MHCII Tetramers to detect endogenous Calnexin specific CD4 T cells, published October 2015.
  • 20140271720 - Method of treating fungal infection, published September 2014.
  • 20140094494 - Antifungal treatment, published April 2014.
  • 20130164766 - Isolation and application of BAD-1 for diagnosing infections with blastomyces dermatitidis, published June 2013.
  • 20080038201 - Global regulator of morphogenesis and pathogenicity in dimorphic fungi and uses thereof, published February 2008.
Recent Publication(s)
  • The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure. Garfoot AL, Shen Q, Wüthrich M, Klein BS, Rappleye CA. MBio. 2016 Apr 19;7(2). pii: e01388-15. doi: 10.1128/mBio.01388-15.

  • Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Sterkel AK, Lorenzini JL, Fites JS, Subramanian Vignesh K, Sullivan TD, Wuthrich M, Brandhorst T, Hernandez-Santos N, Deepe GS Jr, Klein BS. Cell Host Microbe. 2016 Mar 9;19(3):361-74. doi: 10.1016/j.chom.2016.02.001. Epub 2016 Feb 25.

  • The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia. Muñoz JF, Gauthier GM, Desjardins CA, Gallo JE, Holder J, Sullivan TD, Marty AJ, Carmen JC, Chen Z, Ding L, Gujja S, Magrini V, Misas E, Mitreva M, Priest M, Saif S, Whiston EA, Young S, Zeng Q, Goldman WE, Mardis ER, Taylor JW, McEwen JG, Clay OK, Klein BS, Cuomo CA. PLoS Genet. 2015 Oct 6;11(10):e1005493. doi: 10.1371/journal.pgen.1005493. eCollection 2015 Oct.

  • Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase. Beaussart A, Brandhorst T, Dufrêne YF, Klein BS. MBio. 2015 Sep 22;6(5):e01403-15. doi: 10.1128/mBio.01403-15.

View Bruce Klein's publications at PubMed.
Recent Artistic Works
  • University of Cincinnati
  • Intra-University Collaboration: Pediatrics, Internal Medicine
  • Louisiana State University
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-263-9217
Current University UW–Madison
Department Medical Microbiology and Immunology / Medicine
Title Professor
Other Appointments
Address Line 1 4303 Microbial Sciences
Address Line 2 1550 Linden Drive
City Madison
State WI
Zip Code 53706
Bachelor's Degree B.A., Boston University, 1974
Master's Degree
Other Degrees M.D., Boston University, 1978
Technologies Available for Licensing Recombinant, Attenuated Vaccine for Blastomyces Dermatitidis to Prevent Fungal Infection

Global Regulator of Morphogenesis and Pathogenicity in Dimorphic Fungi

Assay to Determine Risk of Fungal Infection

Vaccine for Fungal Infections

Diagnostic Kit for Blastomycosis