Researcher: Charles Mistretta

Areas of Research Expertise
  • Digital subtraction angiography
  • Imaging and characterizing coronary artery lesions
  • Investigations of non-invasive techniques for magnetic resonance imaging of the cardiovascular system
  • Quantitation of flow
  • Coronary artery imaging and flow measurement
  • MR myocradial perfusion
Web Site Charles Mistretta's University Web Page
Curriculum Vitae (CV)
Current/Active Funding
  • NIH, 2010-2016, Accelerated neuro-MRA using compressed sensing and constrained reconstruction
  • NIH, 2010-2016, Periodic contrast-enhanced CT with HYPR reconstruction for ablation monitoring
  • Siemens Medical Solutions USA, Inc, 2011-2015, Addendum #8 to master research agreement between Board of Regents of the University of Wisconsin System and Siemens Medical Solutions USA, Inc
  • NIH, 2013-2016, 4D DSA and 4D fluoroscopy: Validation of diagnostic and therapeutic capabilities
  • Wisconsin Alumni Research Foundation, 2015-2016, Robert Draper Technology Innovation Funding (TIF) for "7D digital subtraction angiography"
Issued Patent(s)
  • 8,963,919 - System and method for four dimensional angiography and fluoroscopy, issued February 2015.
  • 8,768,031 - Time resolved digital subtraction angiography perfusion measurement method, apparatus and system, issued July 2014.
  • 8,755,584 - System and method for filtration reduced equalized exposure computed tomography, issued June 2014.
  • 8,825,138 - Method for reducing motion artifacts in highly constrained medical images, issued September 2014.
  • 8,823,704 - System and method of time-resolved, three-dimensional angiography, issued September 2014
USPTO Published Applications
  • 20130108013 - System and method for improved energy series of images using multi-energy CT, published May 2013.
  • 20100286504 - Contrast enhanced MRA with highly constrained backprojection reconstruction using phase contrast composite image, published November 2010.
  • 20070167707 - Reconstruction method for images of the beating heart, published July 2007.
  • 20070106149 - Image reconstruction method for cardiac gated magnetic resonance imaging, published May 2007.
  • 20070009080 - Backprojection reconstruction method for CT imaging, published January 2007.
Recent Publication(s)
  • Simultaneous static and cine nonenhanced MR angiography using radial sampling and highly constrained back projection reconstruction. Koktzoglou I, Mistretta CA, Giri S, Dunkle EE, Amin P, Edelman RR. Magn Reson Med. 2014 October;72(4):1079-1086. doi: 10.1002/mrm.25008. Epub 2013 November 11.
  • Noncontrast dynamic 3D intracranial MR angiography using pseudo-continuous arterial spin labeling (PCASL) and accelerated 3D radial acquisition. Wu H, Block WF, Turski PA, Mistretta CA, Rusinak DJ, Wu Y, Johnson KM. J Magn Reson Imaging. 2014 May;39(5):1320-1326. doi: 10.1002/jmri.24279. Epub 2013 October 15.
  • Design of a digital beam attenuation system for computed tomography. Part II. Performance study and initial results. Szczykutowicz TP, Mistretta CA. Med Phys. 2013 February;40(2):021906. doi: 10.1118/1.4773880.
  • Design of a digital beam attenuation system for computed tomography: Part I. System design and simulation framework. Szczykutowicz TP, Mistretta CA. Med Phys. 2013 February;40(2):021905. doi: 10.1118/1.4773879.
Recent Artistic Works
  • NorthShore University HealthSystem, Radiology
  • University of Chicago, Medicine
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-9685
Current University UW–Madison
Department Medical Physics / Radiology / Biomedical Engineering
Title Professor Emeritus
Other Appointments
Address Line 1 1139 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.S., University of Illinois, Engineering Physics, 1962
Master's Degree M.S., Harvard University, Physics, 1964
PhD Ph.D., Harvard University, High Energy Physics, 1968
Other Degrees
Technologies Available for Licensing Ultra-High Frame Rate, Time-Resolved, 4-D MRA

Dual Resolution Acquisition of Magnetic Resonance Angiography Data with Vessel Segmentation

Enhanced Method for Vessel Segmentation to Improve Magnetic Resonance Angiography Images

Fourier Space Tomographic Image Reconstruction Method

Magnetic Resonance Angiography Using Floating Table Projection Imaging

Three-Dimensional Phase Contrast Imaging Using Interleaved Projection Data

Time-Resolved, Computed Tomographic Angiography

Phase Contrast MRI with Dual Velocity-Encoded Projection Reconstruction Acquisition

X-Ray System for Use in Image-Guided Procedures

Highly Constrained Backprojected Reconstruction (HYPR) for Magnetic Resonance Images

Highly Constrained Backprojected Reconstruction (HYPR) for Computed Tomography Images

Highly Constrained Image Reconstruction for Magnetic Resonance Spectroscopy

Highly Constrained Image Reconstruction for Medical Imaging Applications

Image Reconstruction Method for Cardiac Gated Magnetic Resonance Imaging

Image Reconstruction Method for Functional Magnetic Resonance Imaging

Diffusion Tensor Imaging Using Highly Constrained Image Reconstruction Method

Image Reconstruction Method for Motion Encoded Magnetic Resonance Images

Highly Constrained Image Reconstruction (HYPR) for Ultrasound Imaging

Two-Dimensional Phase Contrast Imaging Using Interleaved Projection Data

Magnetic Resonance Angiography with Vessel Segmentation

Reducing Image Noise and X-ray Dose in Spectral CT

High-Speed Computed Tomography System Using a Spherical Anode for Improved Medical Imaging

Night Vision System, Device and Method for Enhanced Signal-to-Noise Ratio

Image Reconstruction Method for Computed Tomography and Magnetic Resonance Cardiac Imaging

Improved Highly Constrained Image Reconstruction (HYPR) Method