Researcher: James Zagzebski

Areas of Research Expertise
  • Advanced dosimetry
  • Radiation oncology
  • Biomagnetism
  • Magnetic resonance imaging (MRI)
  • Molecular imaging (WICMIC)
  • Nanotechnology
  • Neutron/proton metrology
  • Nuclear medicine/PET
  • Radiation metrology
  • Radiation calibration
  • Radiation therapy
  • Ultrasound
  • Diagnostic X-ray imaging
  • Quantitative ultrasound imaging for improved detection of breast masses, thyroid nodules, and focal and diffuse liver disease
  • Speed of sound estimation using pulse-echo imaging devices
  • Ultrasound contrast agents
  • Performance specification and acceptance testing of gray scale and Doppler ultrasound imaging systems
Web Site James Zagzebski's Department of Medical Physics Website
Curriculum Vitae (CV)
Current/Active Funding
  • NIH, 2013-2018, Real-time ultrasonic monitoring of tumor ablation
Issued Patent(s)
  • 8,111,810 - Method for producing highly constrained ultrasound images, issued February 2012.
  • 7,601,122 - Ultrasonic elastography with angular compounding, issued October 2009.
  • 7,331,926 - Ultrasonic elastography providing axial, orthogonal, and shear strain, issued February 2008.
  • 7,297,116 - Method and apparatus for imaging the cervix and uterine wall, issued November 2007.
  • 7,275,439 - Parametric ultrasound imaging using angular compounding, issued October 2007.
USPTO Published Applications
  • 20090129651 - Method for producing highly constrained ultrasound images, published May 2009.
  • 20050165309 - Ultrasonic elastography providing axial, orthogonal, and shear strain, published July 2005.
  • 20040243001 - Parametric ultrasound imaging using angular compounding, published December 2004.
  • 20040215075 - Ultrasonic elastography with angular compounding, published October 2004.
Recent Publication(s)
  • Techniques and evaluation from a cross-platform imaging comparison of quantitative ultrasound parameters in an in vivo rodent fibroadenoma model. Wirtzfeld LA, Nam K, Labyed Y, Ghoshal G, Haak A, Sen-Gupta E, He Z, Hirtz NR, Miller RJ, Sarwate S, Simpson DG, Zagzebski JA, Bigelow TA, Oelze M, Hall TJ, O'Brien WD. IEEE Trans Ultrason Ferroelectr Freq Control. 2013 July;60(7):1386-1400. doi: 10.1109/TUFFC.2013.2711.

  • Task-oriented comparison of power spectral density estimation methods for quantifying acoustic attenuation in diagnostic ultrasound using a reference phantom method. Rosado-Mendez IM, Nam K, Hall TJ, Zagzebski JA. Ultrason Imaging. 2013 July;35(3):214-234. doi: 10.1177/0161734613495524.

  • Positron emission tomography imaging of angiogenesis in a murine hindlimb ischemia model with 64Cu-labeled TRC105. Orbay H, Zhang Y, Hong H, Hacker TA, Valdovinos HF, Zagzebski JA, Theuer CP, Barnhart TE, Cai W. Mol Pharm. 2013 July 1;10(7):2749-2756. doi: 10.1021/mp400191w. Epub 2013 June 17.

  • Quantitative assessment of in vivo breast masses using ultrasound attenuation and backscatter. Nam K, Zagzebski JA, Hall TJ. Ultrason Imaging. 2013 April;35(2):146-161. doi: 10.1177/0161734613480281.

View James Zagzebski's publications at PubMed.
Recent Artistic Works
  • Intra-University Collaboration: Radiology, Pathology, Surgery, Oncology
  • University of Tennessee, Radiology
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-265-4929
Current University UW–Madison
Department Medical Physics / Radiology / Human Oncology
Title Emeritus Professor
Other Appointments
Address Line 1 1005 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.A., St. Mary's College, Physics
Master's Degree M.S., UW–Madison, Physics
PhD Ph.D., UW–Madison, Radiological Sciences, 1972
Other Degrees
Technologies Available for Licensing New Elastography Technique That Provides Direct Estimates of All Strain Tensor Components

Elastographic Imaging of Soft Tissue in Vivo

Method and Apparatus for Cardiac Elastography

Parametric Ultrasound Imaging by Using Angular Compounding to Reduce Statistical Variability

Elastographic Imaging of the Cervix and Uterine Wall

Highly Constrained Image Reconstruction (HYPR) for Ultrasound Imaging