Researcher: Randal Tibbetts

Areas of Research Expertise
  • Molecular and cancer biology
  • Medical imaging
  • Radiation physics
  • Bioinformatics
  • Biostatistics
  • Neuro-oncology
  • Pediatric
  • Breast
  • Lung
  • Molecular mechanisms of genome surveillance and neurodegeneration
  • A protein kinase named ATM (ataxia-telangiectasia-mutated)
  • Ataxia-telangiectasia (A-T)
  • CREB transcription factor
  • DNA damage signaling and genome protection.
  • Functional characterization of ALS-associated genes
Web Site Randal Tibbetts' Department of Human Oncology Website
Curriculum Vitae (CV)
Current/Active Funding
  • WARF, 2004-2020, Laboratory share of royalty and licensing - professor Randal S Tibbetts
  • NIH, 2015-2017, Mechanisms of mitochondrial damage in ataxia-telangiectasia
  • NIH, 2016-2017, Genome maintenance functions of CREB/ATF transcription factors
Issued Patent(s)
USPTO Published Applications
Recent Publication(s)
  • Tunable regulation of creb dna binding activity couples genotoxic stress response and metabolism. Kim SH, Trinh AT, Larsen MC, Mastrocola AS, Jefcoate CR, Bushel PR,Tibbetts RS. Nucleic Acids Res. 2016 Jul 18. pii: gkw643. [Epub ahead of print]

  • Neurodegeneration: Problems at the nuclear pore. Fox BW, Tibbetts RS. Nature. 2015 Sep 3;525(7567):36-7. doi: 10.1038/nature15208. Epub 2015 Aug 26. No abstract available.

  • Opposing roles of p38 and jnk in a drosophila model of tdp-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration. Zhan L, Xie Q, Tibbetts RS. Hum Mol Genet. 2015 Feb 1;24(3):757-72. doi: 10.1093/hmg/ddu493. Epub 2014 Oct 3.

  • The rna-binding protein fused in sarcoma (fus) functions downstream of poly(adp-ribose) polymerase (parp) in response to dna damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5.
Recent Artistic Works
Research Tools
Research Facilities
E-mail Address [email protected]
Phone Number 608-262-0027
Current University UW–Madison
Department Human Oncology
Title Professor
Other Appointments
Address Line 1 3059 Wisconsin Institutes for Medical Research
Address Line 2 1111 Highland Avenue
City Madison
State WI
Zip Code 53705
Bachelor's Degree B.S., University of Minnesota, Chemistry/Biochemistry
Master's Degree
PhD Ph.D., Northwestern University, Microbiology-Immunology
Other Degrees Postdoc Fellow, Duke University, Cancer Biology
Technologies Available for Licensing Novel Assay for Measuring Stress-Induced CREB Phosphorylation

Phospho-Specific Antibody to Study Circadian Rhythm Gene PER2