Researcher: Giulio Tononi

Areas of Research Expertise
  • Neural basis of consciousness
  • Functions of sleep
  • How the activities of functionally specialized areas of the brain can be integrated to give rise to a unified conscious scene
  • Genetic dissection of sleep using mutant screening and genetic manipulation available in Drosophila
  • Synaptic homeostasis hypothesis
  • Integrated information theory of consciousness
Web Site Giulio Tononi's Department of Neuroscience Training Program Website
Curriculum Vitae (CV)
Current/Active Funding
  • Philips Healthcare, 2009-2016, Respironics slow wave induction protocol
  • Baycrest, 2011-2016, Brain network recovery group ii
  • NIH, 2013-2018, The cost of plasticity: from cells to systems
  • Templeton World Charity Fdn, 2013-2016, Integrated information as maximally irreducible causation: theoretical and empirical implications for emergence, adaptation, and consciousness
  • NIH, 2014-2019, Do single neurons need to sleep and why?
  • NIH, 2015-2017, Establishing a biomarker for reflective awareness in brain-injured patients
  • Philips Healthcare, 2014-2018, Philips specific research plan for smartnap project exhibit b-10
  • NIH, 2016-2020, Cortico-thalamic mechanisms of anesthetic unconsciousness
  • NIH, 2016-2018, The cost of plasticity: from cells to systems
  • NIH, 2016-2018, Characterizing epileptic spikes as travelling waves using high-density eeg
Issued Patent(s)
  • 8,029,431 - Method and apparatus for promoting restorative sleep, issued October 2011.
  • 7,468,178 - Methods for identifying compounds that modulate vigilance states, issued December 2008.
USPTO Published Applications
  • 20160198968 - Monitoring the effects of sleep deprivation using neuronal avalanches, published July 2016.
  • 20160082222 - Adjustment of sensory stimulation intensity to enhance sleep slow wave activity, published March 2016.
  • 20160058970 - System and method for sleep session management based on slow wave sleep activity in a subject, published March 2016.
  • 20150374951 - System and method for enhanced knowledge consolidation by sleep slow wave induction and sensory context re-creation, published December 2015.
  • 20150359482 - Sensory stimuli to increase accuracy of sleep staging, published December 2015.
Recent Publication(s)
  • What are sleep spindle deficits telling us about schizophrenia? Ferrarelli F, Tononi G. Biol Psychiatry. 2016 Oct 15;80(8):577-8. doi: 10.1016/j.biopsych.2016.08.012. No abstract available.

  • Scalp and source power topography in sleepwalking and sleep terrors: A high-density eeg study. Castelnovo A, Riedner BA, Smith RF, Tononi G, Boly M, Benca RM. Sleep. 2016 Oct 1;39(10):1815-1825.

  • Stratification of unresponsive patients by an independently validated index of brain complexity. Casarotto S, Comanducci A, Rosanova M, Sarasso S, Fecchio M, Napolitani M, Pigorini A, Casali AG, Trimarchi PD, Boly M, Gosseries O, Bodart O, Curto F, Landi C, Mariotti M, Devalle G, Laureys S, Tononi G, Massimini M. Ann Neurol. 2016 Sep 22. doi: 10.1002/ana.24779.

  • Propofol anesthesia reduces lempel-ziv complexity of spontaneous brain activity in rats. Hudetz AG, Liu X, Pillay S, Boly M, Tononi G. Neurosci Lett. 2016 Aug 15;628:132-5. doi: 10.1016/j.neulet.2016.06.017. Epub 2016 Jun 9.
Recent Artistic Works
  • Intra-University Collaboration: Neurology
  • University of Liege, Neurology
  • Riken Brain Science Institute
  • University of Milan, Biomedical and Clinical Sciences
  • Brown University
  • University of Illinois
  • University Children's Hospital in Zurich, Switzerland
  • University of Milan, Clinical Sciences
  • Allen Institute for Brain Science
  • University of Pisa, Clinical Psychology
  • City University of New York, Physiology and Pharmacology
Research Tools
  • Transcranial Magnetic Stimulation (TMS)
  • High Density Electroencephalogram (hdEEG)
Research Facilities
  • Center for Sleep and Consciousness
E-mail Address [email protected]
Phone Number 608-263-6063
Current University UW–Madison
Department Psychiatry
Title Professor
Other Appointments
Principal Investigator, Center for Sleep and Consciousness
Academic Program Director
Address Line 1 9601 UW Psychiatric Institute and Clinics
Address Line 2 6001 Research Park Boulevard
City Madison
State WI
Zip Code 53719
Bachelor's Degree
Master's Degree
PhD Ph.D., Scuola Superiore di Studi Universitari e di Perfezionamento S. Anna, Italy, 1989
Other Degrees M.D., University of Pisa, Italy, 1985
Technologies Available for Licensing Drug-Free Method and Device for Promoting Restorative Sleep

Monitoring Consciousness for Improved Anesthesia Delivery

Ultra-Efficient Continuous Monitoring of Sensors